Bemethyl
Based on 1 Customer Validation
Bemethyl is a synthetic adaptogen that exhibits actoprotector and antihypoxant activities. Bemethyl has the ability to increase the body's resistance to stress and improve physical endurance. Bemethyl regulatory mechanisms include vasodilation and lowering blood sugar and lactate levels. Bemethyl is an analytical reference standard for adaptogen.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 14610-11-8
- 分子式: C9H10N2S
- 分子量:178.25
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Bemethyl serves as a protective agent; research focuses on its capacity to delay fatigue, as well as the underlying mechanisms by which it enhances athletic performance. It also functions as an anti-hypoxic agent, with studies evaluating its protective effects on tissues and cells under hypoxic conditions. Furthermore, Bemethyl is commonly utilized to investigate its role in facilitating physiological adaptation during simulated high-intensity exercise or exposure to specific environments (such as high altitudes).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14610-11-8
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性状 Solid
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分子量 178.25
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分子式 C9H10N2S
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SMILES
CCSC1=NC2=C(N1)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (1402.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (11.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Belinskaia DA, et al. Investigation of Bemethyl Biotransformation Pathways by Combination of LC-MS/HRMS and In Silico Methods. Int J Mol Sci. 2021;22(16):9021. Published 2021 Aug 21. [Content Brief]
[2]. Todorova V, et al. Plant Adaptogens-History and Future Perspectives. Nutrients. 2021;13(8):2861. Published 2021 Aug 20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6101 mL | 28.0505 mL | 56.1010 mL | 140.2525 mL |
| 5 mM | 1.1220 mL | 5.6101 mL | 11.2202 mL | 28.0505 mL | |
| 10 mM | 0.5610 mL | 2.8050 mL | 5.6101 mL | 14.0252 mL | |
| 15 mM | 0.3740 mL | 1.8700 mL | 3.7401 mL | 9.3502 mL | |
| 20 mM | 0.2805 mL | 1.4025 mL | 2.8050 mL | 7.0126 mL | |
| 25 mM | 0.2244 mL | 1.1220 mL | 2.2440 mL | 5.6101 mL | |
| 30 mM | 0.1870 mL | 0.9350 mL | 1.8700 mL | 4.6751 mL | |
| 40 mM | 0.1403 mL | 0.7013 mL | 1.4025 mL | 3.5063 mL | |
| 50 mM | 0.1122 mL | 0.5610 mL | 1.1220 mL | 2.8050 mL | |
| 60 mM | 0.0935 mL | 0.4675 mL | 0.9350 mL | 2.3375 mL | |
| 80 mM | 0.0701 mL | 0.3506 mL | 0.7013 mL | 1.7532 mL | |
| 100 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4025 mL |
Bemethyl 関連分類
HY-W030562 関連分類
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