BLT-3
BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 109940-24-1
- 分子式: C19H13NO
- 分子量:271.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BLT-3 inhibits SR-BI-mediated DiI uptake from DiI-HDL in ldlA[mSR-BI] cells, with an IC50 of 0.51 μM[1].
BLT-3 inhibits SR-BI-mediated [3H]CE uptake from [3H]CE-HDL in ldlA[mSR-BI] cells, with an IC50 of 2.3 μM[1].
BLT-3 inhibits SR-BI-mediated [3H]CE uptake from [3H]CE-HDL in Y1-BS1 cells, with an IC50 of 1.7 μM[1].
BLT-3 inhibits SR-BI-mediated [3H]cholesterol efflux to HDL in ldlA[mSR-BI] cells, with an IC50 of 17.2 μM[1].
BLT-3 enhances the binding of 125I-HDL to SR-BI in ldlA[mSR-BI] cells by increasing binding affinity (decreasing Kd and Koff) without altering Bmax, with an IC50 of 46.5 μM for its binding-enhancing effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 109940-24-1
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分子量 271.32
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分子式 C19H13NO
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SMILES
N=1OC(C=2C=CC=CC2)=C3C=CC=C3C1C=4C=CC=CC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BLT-3 関連分類
HY-120433 関連分類
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