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製品番号: HY-117124

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BMS-337197

BMS-337197 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor.

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CAS 番号: 267645-83-0
分子式: C₂₆H₂₇N₅O₅
分子量:489.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BMS-337197 構造式

CAS 番号: 267645-83-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

BMS-337197 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	0.52 μM Compound: 30a	Inhibition of CEM cell proliferation. Inhibition of CEM cell proliferation.	[PMID: 12781195]
CCRF-CEM	IC₅₀	0.59 μM Compound: 23	In vitro secondary T-cell (CEM) proliferation assay In vitro secondary T-cell (CEM) proliferation assay	[PMID: 12014950]
CCRF-CEM	IC₅₀	520 nM Compound: BMS-337197	Inhibition of CEM (human leukemia) cell proliferation. Inhibition of CEM (human leukemia) cell proliferation.	[PMID: 14505670]
CCRF-CEM	IC₅₀	590 nM Compound: BMS-337197	Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM) Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM)	[PMID: 12392738]

体外実験

BMS-337197 is an inhibitor of inosine monophosphate dehydrogenase (IMPDH)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 267645-83-0
分子量 489.52
分子式 C₂₆H₂₇N₅O₅
SMILES

O=C(N(C1=CC=CC=C1C2=CN=C(NC3=CC=C(C4=CN=CO4)C(OC)=C3)O2)C)CN5CCOCC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Dhar TG, et al. A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues. Org Lett. 2002;4(12):2091-2093. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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