BMS-433771
Based on 1 Customer Validation
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 543700-68-1
- 分子式: C21H23N5O2
- 分子量:377.44
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Antiviral Compound Library
HY-L027
-
Orally Active Compound Library
HY-L061
-
Heterocyclic Compound Library
HY-L138
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
生物活性
EC50: 20 nM (RSV)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
13 nM
Compound: 1
|
Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
|
[PMID: 23265891] |
| HeLa | CC50 |
>100 μM
Compound: 4; BMS-433771
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
|
[PMID: 32407115] |
| HEp-2 | CC50 |
>100 μM
Compound: 5, BMS-433771
|
Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
|
[PMID: 25941547] |
| HEp-2 | EC50 |
0.028 μM
Compound: 5, BMS-433771
|
Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
|
[PMID: 25941547] |
| HEp-2 | CC50 |
>100 μM
Compound: 3; BMS433771
|
Cytotoxicity against human Hep2 cells after 4 days
Cytotoxicity against human Hep2 cells after 4 days
|
[PMID: 28772235] |
| HEp-2 | CC50 |
>100 μM
Compound: BMS-433771
|
Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
|
[PMID: 29456794] |
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:rodent models of RSV infection[2]
(cotton rat and mice) -
Dosage:1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
-
Administration:oral, single or bid 4 days
-
Result:Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
化学情報
-
CAS 番号 543700-68-1
-
性状 Solid
-
分子量 377.44
-
分子式 C21H23N5O2
-
Color White to off-white
-
SMILES
O=C(N(C1=C2C=CN=C1)CC3=NC4=CC=CC=C4N3CCCCO)N2C5CC5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 6.25 mg/mL (16.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2.5 mg/mL (6.62 mM; ultrasonic and adjust pH to 4 with HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [Content Brief]
[2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.6494 mL | 13.2471 mL | 26.4943 mL | 66.2357 mL |
| 5 mM | 0.5299 mL | 2.6494 mL | 5.2989 mL | 13.2471 mL | |
| DMSO | 10 mM | 0.2649 mL | 1.3247 mL | 2.6494 mL | 6.6236 mL |
| 15 mM | 0.1766 mL | 0.8831 mL | 1.7663 mL | 4.4157 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BMS-433771 関連分類
HY-120632 関連分類
Powered by Bioz