BMS-502
Based on 1 publication(s) in Google Scholar
BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.31%
- CAS 番号: 2407854-18-4
- 分子式: C27H22F2N6O3
- 分子量:516.50
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 BMS-502
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生物活性
IC50: 4.6 nM (DGK α), 2.1nM (DGK ζ)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Raji | IC50 |
0.037 μM
Compound: 22; BMS-502
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Cytotoxicity against PD-1 negative human Raji cells measured after 24 hrs by Cell titer glo assay
Cytotoxicity against PD-1 negative human Raji cells measured after 24 hrs by Cell titer glo assay
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[PMID: 37465293] |
| Raji | IC50 |
0.037 μM
Compound: 22; BMS-502
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Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cell titer glo assay
Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cell titer glo assay
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[PMID: 37465293] |
Pharmacokinetic Analysis in C57 black mice Model[1]
| Route | Dose (mg/kg) | AUClast (μM•h) | t1/2 (h) | Tmax (h) | Cmax (μM) | Cl (m/min/kg) | Vss (mL/kg) | F (%) |
| i.v. | 1 | 14.8 | 22.5 | / | / | 1.9 | 3.9 | / |
| p.o. | 5 | 48 | / | 3.0 | 1.08 | / | / | 65 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OT-1 mouse model[1]
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Dosage:0-10 mg/kg
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Administration:Oral administration; 24 h
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Result:Caused no significant increase in activated effector T-cells.
化学情報
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CAS 番号 2407854-18-4
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性状 Solid
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分子量 516.50
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分子式 C27H22F2N6O3
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Color Light yellow to yellow
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SMILES
N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
In Cellulo pharmacological profiling and genomic editing reveals paralog-specific targets for PA generation during PLC signaling. [Abstract]2026 Mar 12:2026.03.02.709100. PMID: 41867796
溶剤 & 溶解度
DMSO : 100 mg/mL (193.61 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9361 mL | 9.6805 mL | 19.3611 mL | 48.4027 mL |
| 5 mM | 0.3872 mL | 1.9361 mL | 3.8722 mL | 9.6805 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9361 mL | 4.8403 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2907 mL | 3.2268 mL | |
| 20 mM | 0.0968 mL | 0.4840 mL | 0.9681 mL | 2.4201 mL | |
| 25 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9361 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6134 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2101 mL | |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9681 mL | |
| 60 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6050 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL |
BMS-502 関連分類
HY-149874 関連分類
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