BMS-986497
Based on 1 Customer Validation
BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.59%
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保管条件:
-80°C
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Eukaryotic Release Factor (eRF) アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic activity in CD33-expressing AML cell lines, including Mylotarg-resistant AML193 and Kasumi6 cell lines, with 10-1000-fold greater potency than reference GSPT1 degrader molecules[1].
ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic potency in primary relapsed/refractory AML patient blasts, with better potency than CC-90009 and Mylotarg[1].
ORM-6151 (BMS-986497) exhibits minimal cytotoxic activity in healthy hematopoietic progenitor cells, with 10-10,000-fold less toxicity than CC-90009 or Mylotarg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:xenograft model[1]
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Dosage:1 mg/kg
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Administration:single treatment
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Result:Demonstrated robust anti-tumor efficacy, with superior activity compared to CC-90009.
Showed tumor growth inhibition correlated with the degree and duration of GSPT1 depletion and changes in expression of integrated stress response biomarker genes.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[BMS-986497]
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別名
ORM-6151
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輸送条件
Shipping with dry ice.
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保管条件
-80°C
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS-986497 関連分類
HY-171792 関連分類
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Keywords
- BMS-986497
- ORM-6151
- BMS986497
- BMS 986497
- ORM6151
- ORM 6151
- Antibody-Drug Conjugates (ADCs)
- Eukaryotic Release Factor (eRF)
- Transmembrane Glycoprotein
- CD33
- acute myeloid leukemia xenograft models
- myelodysplastic neoplasms
- AML193
- Kasumi6
- acute myeloid leukemia cells
- healthy hematopoietic progenitor cells
- MV4-11
- GSPT1
- primary relapsed/refractory acute myeloid leukemia blasts
- Inhibitor
- inhibitor
- inhibit