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United States

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製品番号: HY-189685

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BPI-361175

BPI-361175 is an orally active and blood-brain barrier-penetrant EGFR inhibitor. BPI-361175 inhibits EGFR tyrosine kinase activity and exhibits higher selectivity for mutant EGFR over wild-type EGFR. BPI-361175 can be used for research on non-small cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2595202-07-4
分子式: C₃₀H₃₇BrN₇O₃P
分子量:654.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BPI-361175 構造式

CAS 番号: 2595202-07-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

EGFR アイソフォーム固有の製品をすべて表示 :

体外実験

BPI-361175 (0.7-465 nM) inhibits Ba/F3-EGFR-19del/T790M/C797S-TK and Ba/F3-EGFR-L858R/T790M/C797S-TK with IC₅₀ values of 0.7 nM and 3.6 nM, respectively, while showing reduced wild-type EGFR activity (IC₅₀ = 465 nM)^[1].
BPI-361175 potently inhibits EGFR kinase activity across triple, double, and single EGFR mutant forms (EGFRdel19 or L858R/T790M/C797S; EGFRdel19 or L858R/T790M; EGFRdel19 or L858R/C797S; EGFRdel19; EGFRL858R) while showing no activity against EGFRWT and IGF1R in cell-free assays^[2].
BPI-361175 dose-dependently inhibits EGFR phosphorylation and proliferation in cell lines harboring triple, double, and single EGFR mutations (EGFRdel19 or L858R/T790M/C797S; EGFRdel19 or L858R/T790M; EGFRdel19 or L858R/C797S; EGFRdel19; EGFRL858R) and lacks activity against EGFRWT and IGF1R in cell-based assays^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 2595202-07-4
分子量 654.54
分子式 C₃₀H₃₇BrN₇O₃P
SMILES

CCN1C=C(C=N1)C2=CC(NC3=NC(NC4=CC=C(C(C)=C4P(C)(C)=O)C)=C(C=N3)Br)=C(C=C2N5CCOCC5)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kadam VM, et al. Recent advances in synthetic strategies of fourth-generation EGFR tyrosine kinase inhibitors under clinical trials for the treatment of resistant non-small cell lung cancer (NSCLC). Bioorganic chemistry. 2026 Oct 05;181:110353.

[2]. Liu L, e al. Abstract 5462: BPI-361175, a 4th generation EGFR-TKI for the treatment of non-small cell lung cancer (NSCLC). Cancer Res. 2022;82(12_Supplement):5462.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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