Bremelanotide
Based on 1 publication(s) in Google Scholar
Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.69%
- CAS 番号: 189691-06-3
- 分子式: C50H68N14O10
- 分子量:1025.16
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Bremelanotide
More
生物活性
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MC4R |
MC3R |
Bremelanotide (10−3-105 nM) binds to MC3R and MC4R in a concentration-dependent manner[3].
Bremelanotide induces cAMP accumulation in cell-free assays with EC50 values of 0.4 nM for MC3R and 0.2 nM for MC4R[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)[1]
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Dosage:50, 100, 200 μg/kg
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Administration:Subcutaneously injection
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Result:Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Increased solicitations in estradiol-alone primed rats at 200 μg/kg.
Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Induced female mounting behavior at 200 μg/kg.
化学情報
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CAS 番号 189691-06-3
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性状 Solid
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分子量 1025.16
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分子式 C50H68N14O10
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Color White to off-white
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別名
PT-141
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Pharm
2022 Nov 7;19(11):4320-4332. PMID: 36269563
溶剤 & 溶解度
H2O : 100 mg/mL (97.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007;4 Suppl 4:269-279. [Content Brief]
[3]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9755 mL | 4.8773 mL | 9.7546 mL | 24.3864 mL |
| 5 mM | 0.1951 mL | 0.9755 mL | 1.9509 mL | 4.8773 mL | |
| 10 mM | 0.0975 mL | 0.4877 mL | 0.9755 mL | 2.4386 mL | |
| 15 mM | 0.0650 mL | 0.3252 mL | 0.6503 mL | 1.6258 mL | |
| 20 mM | 0.0488 mL | 0.2439 mL | 0.4877 mL | 1.2193 mL | |
| 25 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9755 mL | |
| 30 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8129 mL | |
| 40 mM | 0.0244 mL | 0.1219 mL | 0.2439 mL | 0.6097 mL | |
| 50 mM | 0.0195 mL | 0.0975 mL | 0.1951 mL | 0.4877 mL | |
| 60 mM | 0.0163 mL | 0.0813 mL | 0.1626 mL | 0.4064 mL | |
| 80 mM | 0.0122 mL | 0.0610 mL | 0.1219 mL | 0.3048 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Bremelanotide 関連分類
HY-18678 関連分類
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