BTR2004
Based on 1 Customer Validation
BTR2004 is a selective BET family (BRD2/3/4) protein PROTAC degrader. BTR2004 forms a ternary complex with BRD proteins and KLHL20, inducing ubiquitination and proteasomal degradation through the UPS pathway. BTR2004 is promising for research of PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.
(Pink: BET ligand (HY-161125); Blue: Ligands for E3 Ligase ligand (HY-172563); Black: linker (HY-W015236)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.86%
- CAS 番号: 3093583-69-5
- 分子式: C54H66ClN13O11S3
- 分子量:1204.83
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
化学情報
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CAS 番号 3093583-69-5
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性状 Solid
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分子量 1204.83
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分子式 C54H66ClN13O11S3
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Color White to off-white
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SMILES
CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCC(NCC(NCC(N[C@H](C(N5[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CSC6)=O)=O)=O)CCC5)=O)CSCC7=CC=CC6=C7)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (83.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Farrell BM, et al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042. [Content Brief]
[2]. Fechtmeyer PH, et al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv [Preprint]. 2024 Dec 7:2024.12.07.627262. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8300 mL | 4.1500 mL | 8.2999 mL | 20.7498 mL |
| 5 mM | 0.1660 mL | 0.8300 mL | 1.6600 mL | 4.1500 mL | |
| 10 mM | 0.0830 mL | 0.4150 mL | 0.8300 mL | 2.0750 mL | |
| 15 mM | 0.0553 mL | 0.2767 mL | 0.5533 mL | 1.3833 mL | |
| 20 mM | 0.0415 mL | 0.2075 mL | 0.4150 mL | 1.0375 mL | |
| 25 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8300 mL | |
| 30 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.6917 mL | |
| 40 mM | 0.0207 mL | 0.1037 mL | 0.2075 mL | 0.5187 mL | |
| 50 mM | 0.0166 mL | 0.0830 mL | 0.1660 mL | 0.4150 mL | |
| 60 mM | 0.0138 mL | 0.0692 mL | 0.1383 mL | 0.3458 mL | |
| 80 mM | 0.0104 mL | 0.0519 mL | 0.1037 mL | 0.2594 mL |
BTR2004 関連分類
HY-172562 関連分類
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