C3361
C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with Ki values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a Ki of 82 μM. C3361 attenuates hepatic (IC50 = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 91042-00-1
- 分子式: C17H32O6
- 分子量:332.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
C3361 reduces 75% ookinete formation[1].
C3361 (1-100 μM, 68 h) prevent the maturation of the liver-stage schizonts in sporozoite-infected hepatoma cells[1].
C3361 shows growth inhibition of P. berghei with an IC50 of 15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Sporozoite-infected hepatoma cells
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Concentration:1, 10, 50 and 100 μM
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Incubation Time:68 h
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Result:Decreased area of the liver schizonts.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:GFP-expressing parasite-infected blood cells infected mice models[1]
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Dosage:2 mg/kg
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Administration:Intraperitoneally injection, daily
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Result:Reduced 45% parasitemia from days 3-5.
化学情報
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CAS 番号 91042-00-1
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分子量 332.43
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分子式 C17H32O6
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SMILES
C=CCCCCCCCCCO[C@H]1[C@@H]([C@H](OC([C@@H]1O)O)CO)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Huang J, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017749118. [Content Brief]
[2]. Blume M, et al. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J. 2011 Apr;25(4):1218-29. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
C3361 関連分類
HY-17656 関連分類
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