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製品番号: HY-183844

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C5F2-HCB

C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC₅₀ of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER⁺HER2⁻ breast cancer allograft models. C5F2-HCB can be used in research related to ER⁺HER2⁻ breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 2792206-44-9
分子式: C₁₇H₂₅F₂N₅
分子量:337.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

C5F2-HCB 構造式

CAS 番号: 2792206-44-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

C5F2-HCB (18 mg/kg; once daily) inhibits the growth of ER⁺HER2^- SSM2ucd breast cancer xenografts to 49.6-53.3% of the control level, and modulates an immune-repulsive tumor microenvironment by increasing CD8⁺ tumor-infiltrating lymphocytes (TILs), reducing intratumoral regulatory T cells (Tregs), decreasing macrophage numbers and the M2/M1 macrophage ratio, and increasing intratumoral neutrophils^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2792206-44-9
分子量 337.41
分子式 C₁₇H₂₅F₂N₅
SMILES

N=C(NC(NCCCCC(F)(F)C)=N)NCC12[C@H]3[C@H]4[C@@H]1[C@@H]5C4[C@H]3[C@@H]52
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Guo Z, et al. Abstract LB010: C5F2-hexyl-(cuban-1-yl-methyl)-biguanide (C5F2-HCB) overcomes an immune excluded tumor microenvironment (TME) and suppresses tumor growth in the ovarian dependent ER+ HER2-SSM2ucd mammary carcinoma allograft model. Cancer Research. 2025 Apr 25;85(8_Supplement_2):LB010-.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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