Carmustine-d8
Based on 1 Customer Validation
Carmustine-d8 is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.34%
- 分子式: C5HD8Cl2N3O2
- 分子量:222.10
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 154-93-8
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性状 Solid-Liquid Mixture
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分子量 222.10
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分子式 C5HD8Cl2N3O2
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Color Colorless to off-white
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SMILES
[2H]C(Cl)(C([2H])(NC(N(C([2H])(C([2H])(Cl)[2H])[2H])N=O)=O)[2H])[2H]
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別名
BCNU-d8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
H2O : 100 mg/mL (450.25 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Hung CF. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res. 2000 Jun;25(6):845-51. [Content Brief]
[3]. Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res. 2001 May 1;20(1):133-143. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5025 mL | 22.5124 mL | 45.0248 mL | 112.5619 mL |
| 5 mM | 0.9005 mL | 4.5025 mL | 9.0050 mL | 22.5124 mL | |
| 10 mM | 0.4502 mL | 2.2512 mL | 4.5025 mL | 11.2562 mL | |
| 15 mM | 0.3002 mL | 1.5008 mL | 3.0017 mL | 7.5041 mL | |
| 20 mM | 0.2251 mL | 1.1256 mL | 2.2512 mL | 5.6281 mL | |
| 25 mM | 0.1801 mL | 0.9005 mL | 1.8010 mL | 4.5025 mL | |
| 30 mM | 0.1501 mL | 0.7504 mL | 1.5008 mL | 3.7521 mL | |
| 40 mM | 0.1126 mL | 0.5628 mL | 1.1256 mL | 2.8140 mL | |
| 50 mM | 0.0900 mL | 0.4502 mL | 0.9005 mL | 2.2512 mL | |
| 60 mM | 0.0750 mL | 0.3752 mL | 0.7504 mL | 1.8760 mL | |
| 80 mM | 0.0563 mL | 0.2814 mL | 0.5628 mL | 1.4070 mL | |
| 100 mM | 0.0450 mL | 0.2251 mL | 0.4502 mL | 1.1256 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Carmustine-d8 関連分類
HY-13585S 関連分類
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