Catumaxomab
Based on 1 Customer Validation
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.82%
- CAS 番号: 509077-98-9
- 分子量:146.73 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
IgG2a-kappa/G2b-lambda
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD3E & EPCAM
体外実験
Catumaxomab (0-5 ng/mL; 3-7 days) strongly inhibits the growth of FaDu tumor spheroids in coculture with PBMC with a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG2a-kappa/G2b-lambda
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Catumaxomab at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG. Black - Unlabelled control, cells without incubation with primary antibody. -
Immobilized EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P72367) can bind Catumaxomab. The EC50 for this effect is 579.8 ng/mL.
化学情報
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CAS 番号 509077-98-9
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性状 Liquid
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分子量 146.73 kDa
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Color Colorless to light yellow
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SMILES
[Catumaxomab]
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)