Cauloside A
Based on 1 Customer Validation
Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 17184-21-3
- 分子式: C35H56O8
- 分子量:604.81
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
29.71 μM
Compound: 10a
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Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 23992864] |
| A549 | IC50 |
40 μM
Compound: 23
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Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
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[PMID: 19200744] |
| A549 | IC50 |
58 μM
Compound: 23
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Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
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[PMID: 19200744] |
| DLD-1 | IC50 |
54 μM
Compound: 23
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Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
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[PMID: 19200744] |
| DLD-1 | IC50 |
57 μM
Compound: 23
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Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
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[PMID: 19200744] |
| HeLa | IC50 |
27.67 μM
Compound: 10a
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Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 23992864] |
| HepG2 | IC50 |
19.12 μM
Compound: 10a
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Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| HL-60 | IC50 |
14.52 μM
Compound: 10a
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Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| RAW264.7 | IC50 |
2.25 μM
Compound: 14
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
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[PMID: 31301930] |
| U-87MG ATCC | IC50 |
18.45 μM
Compound: 10a
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Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
化学情報
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CAS 番号 17184-21-3
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性状 Solid
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分子量 604.81
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分子式 C35H56O8
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Color White to off-white
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SMILES
C[C@@]1(CC[C@@]2([H])[C@]3(C)CO)[C@@](CC=C([C@]4([H])CC5(C)C)[C@]1(CC[C@]4(CC5)C(O)=O)C)([H])[C@]2(CC[C@@H]3O[C@H](OC[C@@H]6O)[C@@H]([C@H]6O)O)C
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別名
Leontoside A
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (165.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Nam Hee Choi, et al. Antifungal activity of sterols and dipsacus saponins isolated from Dipsacus asper roots against phytopathogenic fungi. Pestic Biochem Physiol. 2017 Sep;141:103-108. [Content Brief]
[2]. Sandipan Datta, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014 Jan 24;77(1):111-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6534 mL | 8.2671 mL | 16.5341 mL | 41.3353 mL |
| 5 mM | 0.3307 mL | 1.6534 mL | 3.3068 mL | 8.2671 mL | |
| 10 mM | 0.1653 mL | 0.8267 mL | 1.6534 mL | 4.1335 mL | |
| 15 mM | 0.1102 mL | 0.5511 mL | 1.1023 mL | 2.7557 mL | |
| 20 mM | 0.0827 mL | 0.4134 mL | 0.8267 mL | 2.0668 mL | |
| 25 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.6534 mL | |
| 30 mM | 0.0551 mL | 0.2756 mL | 0.5511 mL | 1.3778 mL | |
| 40 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0334 mL | |
| 50 mM | 0.0331 mL | 0.1653 mL | 0.3307 mL | 0.8267 mL | |
| 60 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6889 mL | |
| 80 mM | 0.0207 mL | 0.1033 mL | 0.2067 mL | 0.5167 mL | |
| 100 mM | 0.0165 mL | 0.0827 mL | 0.1653 mL | 0.4134 mL |
Cauloside A 関連分類
HY-N3557 関連分類
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