Cefotiam
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 61622-34-2
- 分子式: C18H23N9O4S3
- 分子量:525.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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β-lactam |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
718 μM
Compound: Cefotiam
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TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
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[PMID: 15618660] |
Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1].
Cefotiam (0-6.25μg/mL; 8 h) has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CF1/b mice with P. mirabilis xenograft[1]
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Dosage:12.5, 25, 50, 100, 200, 400 and 800 mg/kg
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Administration:Subcutaneous injection; twice a day, for 5 days
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Result:Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.
化学情報
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CAS 番号 61622-34-2
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分子量 525.63
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分子式 C18H23N9O4S3
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SMILES
O=C(C(N12)=C(CSC3=NN=NN3CCN(C)C)CS[C@]2([H])[C@H](NC(CC4=CSC(N)=N4)=O)C1=O)O
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別名
SCE-963; Cefotiam Dihydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug;18(2):257-63. [Content Brief]
[2]. Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov;10(5):391-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cefotiam 関連分類
HY-B0734 関連分類
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