Cimaterol
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Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.13%
- CAS 番号: 54239-37-1
- 分子式: C12H17N3O
- 分子量:219.28
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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β-adrenoceptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
10 μM
Compound: Cimaterol
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Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
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[PMID: 23614528] |
| CHO-K1 | EC50 |
10 μM
Compound: Cimaterol
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Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
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[PMID: 23614528] |
Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 μM) shows a significant increase of cAMP concentration subsequent drug exposure[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse C2C12 myoblast cells
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Concentration:0.1 and 1 µM
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Incubation Time:8 days
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Result:Fast proliferation with an increase of absorbance was noticed in treated cells compared to untreated cells at days 1, 2, and 3. From day 5 to day 8, the trend was reversed with absorbance in control cells significantly greater than that of treated cells.
Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:One hundred fifty crossbred pigs (55 kg)[4]
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Dosage:Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
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Administration:
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Result:Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.
Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
化学情報
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CAS 番号 54239-37-1
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性状 Solid
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分子量 219.28
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分子式 C12H17N3O
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Color White to off-white
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SMILES
N#CC1=CC(C(O)CNC(C)C)=CC=C1N
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別名
CL 263780; (±)-2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (570.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255(6 Pt 2):R952-60. [Content Brief]
[2]. J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7(4):477-84. [Content Brief]
[3]. Boimpoundi Eunice Flavie Ouali, et al. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021 May 18;26:101019. [Content Brief]
[4]. W R Walker, et al. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67(1):168-76. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5604 mL | 22.8019 mL | 45.6038 mL | 114.0095 mL |
| 5 mM | 0.9121 mL | 4.5604 mL | 9.1208 mL | 22.8019 mL | |
| 10 mM | 0.4560 mL | 2.2802 mL | 4.5604 mL | 11.4009 mL | |
| 15 mM | 0.3040 mL | 1.5201 mL | 3.0403 mL | 7.6006 mL | |
| 20 mM | 0.2280 mL | 1.1401 mL | 2.2802 mL | 5.7005 mL | |
| 25 mM | 0.1824 mL | 0.9121 mL | 1.8242 mL | 4.5604 mL | |
| 30 mM | 0.1520 mL | 0.7601 mL | 1.5201 mL | 3.8003 mL | |
| 40 mM | 0.1140 mL | 0.5700 mL | 1.1401 mL | 2.8502 mL | |
| 50 mM | 0.0912 mL | 0.4560 mL | 0.9121 mL | 2.2802 mL | |
| 60 mM | 0.0760 mL | 0.3800 mL | 0.7601 mL | 1.9002 mL | |
| 80 mM | 0.0570 mL | 0.2850 mL | 0.5700 mL | 1.4251 mL | |
| 100 mM | 0.0456 mL | 0.2280 mL | 0.4560 mL | 1.1401 mL |
Cimaterol 関連分類
HY-100935 関連分類
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