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製品番号: HY-182690

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CK147

CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC₅₀ of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection.

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CAS 番号: 1883356-12-4
分子式: C₃₂H₄₈N₄O₄S₂
分子量:616.88

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CK147 構造式

CAS 番号: 1883356-12-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HIV アイソフォーム固有の製品をすべて表示 :

体外実験

CK147 (0.01-100 μM; 18 h) potently down-modulates human CD4 expression in transiently transfected HEK293T cells with an IC₅₀ of 0.04 μM, achieving 95% maximum reduction^[1].
CK147 (0.01-100 μM; 72 h) is cytotoxic to HEK293T cells with a CC₅₀ of 0.36 μM, significantly reducing cell proliferation after 72 hours of treatment^[1].
CK147 (0.01-100 μM; 72 h) inhibits proliferation of wild-type HCT116 cells with a CC₅₀ of 0.48 μM, but has no effect on proliferation of CK147-resistant HCT116 clones, which have CC₅₀ values >50 μM^[1].
CK147 is the most potent identified CADA analog, down-modulating CD4 expression with an IC₅₀ of 0.058 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human embryonic kidney (HEK) 293T cells
Concentration:

0.01, 0.1, 1, 10 and 100 μM
Incubation Time:

72 h
Result:

Reduces HEK293T cell proliferation in a concentration-dependent manner, with a cytotoxic concentration (CC₅₀) of 0.36 μM.
Reduces proliferation to ≤ 10% of DMSO control levels at concentrations ≥ 0.1 μM.

Cell Proliferation Assay^[1]

Cell Line:

wild-type and CK147-resistant HCT116 human colon cancer cells
Concentration:

0.01, 0.1, 1, 10 and 100 μM
Incubation Time:

72 h
Result:

Inhibits proliferation of wild-type HCT116 cells, with a CC₅₀ of 0.48 μM.
Shows no effect on proliferation of three CK147-resistant HCT116 clones (10, 13, 16), which have CC₅₀ values > 50 μM and proliferation remaining near 100% of DMSO control across all tested concentrations.

化学情報

CAS 番号 1883356-12-4
分子量 616.88
分子式 C₃₂H₄₈N₄O₄S₂
SMILES

O=S(C1=CC=C(N(C)C)C=C1)(N2CC(CN(S(=O)(C3=CC=C(C)C=C3)=O)CCCN(CC4CCCCC4)CCC2)=C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pauwels E, et al. Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. Sci Adv. 2023;9(9):eadf0797. [Content Brief]

[2]. Ali R. Synthesis and CD4 down-modulation potencies of CADA head analogs. University of Nevada, Reno; 2015.

Calculators

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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