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製品番号: HY-P11180

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Clavanin A

Clavanin A is a peptide Antibiotic and membrane permeabilizer. Clavanin A permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A exhibits antibacterial activity against Micrococcus flavus. Clavanin A can be used in studies related to Micrococcus flavus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 185518-51-8
分子式: C₁₃₁H₁₈₄N₃₄O₂₇
分子量:2667.07

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clavanin A 構造式

CAS 番号: 185518-51-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antibiotic アイソフォーム固有の製品をすべて表示 :

体外実験

Clavanin A (starting serial dilution at 500 µg/mL; 24 h) inhibits the growth of Micrococcus flavus (DSM 1790), with an MIC of 4.9 µM^[1].
Clavanin A (0.23 µM) dissipates the membrane potential of intact Micrococcus flavus cells, with inhibition rates reaching 58% and 80% at the concentration of 0.23 µM in two independent experiments^[1].
Clavanin A (1-5 µM; 2 min) permeabilizes DOPC large unilamellar vesicles (LUVs), triggering the release of low-molecular-weight carboxyfluorescein and high-molecular-weight FITC-dextran (9400 Da) in the micromolar concentration range, which indicates a non-specific membrane permeabilization mechanism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 185518-51-8
分子量 2667.07
分子式 C₁₃₁H₁₈₄N₃₄O₂₇
配列

Val-Phe-Gln-Phe-Leu-Gly-Lys-Ile-Ile-His-His-Val-Gly-Asn-Phe-Val-His-Gly-Phe-Ser-His-Val-Phe
シーケンスの短縮

VFQFLGKIIHHVGNFVHGFSHVF
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (258 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. van Kan EJ, et al. Membrane activity of the peptide antibiotic clavanin and the importance of its glycine residues. Biochemistry. 2001;40(21):6398-6405. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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