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製品番号: HY-P5291

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CPF-7

(別名: Caerulein precursor fragment)

CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 103238-06-8
分子式: C₁₁₈H₁₉₃N₃₃O₃₂
分子量:2586.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CPF-7 構造式

CAS 番号: 103238-06-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CPF-7 (50 nM; 7 days) converts PANC-1 exocrine cells into pancreatic endocrine precursor cells^[1].
CPF-7 (3 µM; 20 min) produces the stimulation of insulin release in BRIN-BD11 rat clonal β-cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

PANC1 cells
Concentration:

50 nM
Incubation Time:

7 days (change medium every 24 h)
Result:

Increased Ngn3 (the principal determinant of endocrine precursor cells) expression level.

Immunofluorescence^[2]

Cell Line:

BRIN-BD11 rat clonal β-cells
Concentration:

3 µM
Incubation Time:

20 min
Result:

Stimulated insulin release.

化学情報

CAS 番号 103238-06-8
分子量 2586.00
分子式 C₁₁₈H₁₉₃N₃₃O₃₂
別名

Caerulein precursor fragment
配列

Gly-Phe-Gly-Ser-Phe-Leu-Gly-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Ile-Gly-Ala-Asn-Ala-Leu-Gly-Gly-Ala-Pro-Gln-Gln
シーケンスの短縮

GFGSFLGKALKAALKIGANALGGAPQQ
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133. [Content Brief]

[2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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