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製品番号: HY-P99834

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Biologically Validated

Crefmirlimab

Name: Crefmirlimab
Brand: MedChemExpress
SKU: HY-P99834
Price: 380.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: IAB22M2C; ImaginAb)

カスタマーレビュー

Based on 1 Customer Validation

Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., ⁸⁹Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 97.616%
CAS 番号: 2611099-93-3
分子量:79.946 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Crefmirlimab 構造式

CAS 番号: 2611099-93-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Verified Bioactivity
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

(scFv-kappa-heavy)-h-CH3

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD8A

体内実験

⁸⁹Zr-Df-Crefmirlimab (48-81 μCi; i.v.) enables non-invasive, dose- and time-dependent quantification of intratumoral CD8⁺ T cell recruitment in a human colorectal cancer adoptive transfer mouse model, with moderate correlation to immunohistochemical CD8⁺ T cell density (R² up to 0.46)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD-SCID IL-2Rγ null (NSG) (female)^[1]
Dosage:

48-81 μCi (delivering ~50 μg)
Administration:

i.v.
Result:

Showed substantial uptake in CD8⁺ T cell-rich tissues (spleen and tumors) with minimal accumulation in background tissues (muscle, whole blood).
Detected dose-dependent increases in tumor uptake on day 9 post-bispecific antibody treatment, with a mean SUV of up to 1.54 (SEM) in the highest-dose bispecific antibody group.
Confirmed dose- and time-dependent tumor uptake via ex vivo gamma counting, with a mean tumor uptake of 13.0%ID/g (SEM) in the highest-dose bispecific antibody group on day 9.
Showed moderate correlation between tumor radiotracer uptake (SUV or %ID/g) and CD8⁺ T cell density via immunohistochemistry (R² = 0.46 and R² = 0.45, respectively) on day 9.
Achieved tumor-to-blood ratios >8 and tumor-to-muscle ratios >27 for the highest bispecific antibody dose on day 9.

遺伝子ID

925 [NCBI]

アクセッション番号

P01732

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

(scFv-kappa-heavy)-h-CH3

アプリケーション

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized CD8 alpha Protein, Human (HEK293, His, HY-P71662) can bind Crefmirlimab. The EC₅₀ for this effect is 532.3 ng/mL.

化学情報

CAS 番号 2611099-93-3
性状 Liquid
分子量 79.946 kDa
Color Colorless to light yellow
SMILES

[Crefmirlimab]
別名

IAB22M2C; ImaginAb
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (261 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Maresca KP, et al. Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy. Mol Imaging Biol. 2021 Dec;23(6):941-951. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Biological Activity
化学情報
純度とドキュメンテーション
参考文献

製品名:
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数量:
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Crefmirlimab

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)