Cyanofenphos
Cyanofenphos is an orally active organophosphate insecticide and brain AChE inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 13067-93-1
- 分子式: C15H14NO2PS
- 分子量:303.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AChE |
Cyanofenphos (80 mg/kg; oral; single dose) induces delayed neurotoxicity in hens following cyanofenphos challenge doses, with higher neurotoxicity incidence observed for 200 mg/kg compared to 100 mg/kg challenge doses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic hens (2-3 months old, body weight 1.30-2.00 kg)[2]
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Dosage:80 mg/kg (pretreatment); 100 mg/kg, 200 mg/kg (challenge)
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Administration:oral; single dose (pretreatment); oral; single dose (challenge, 24 hours or 8 days after pretreatment)
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Result:Resulted in 0 acute deaths and 20% (2/10 hens) developing slight ataxia for 100 mg/kg challenge at 24-hour interval.
Resulted in 0 acute deaths and 10% (1/10 hens) developing slight ataxia for 100 mg/kg challenge at 8-day interval.
Resulted in 0 acute deaths and 80% (8/10 hens) developing ataxia for 200 mg/kg challenge at 24-hour interval.
Resulted in 1 acute death and 89% (8/9 surviving hens) developing neurotoxicity for 200 mg/kg challenge at 8-day interval.
化学情報
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CAS 番号 13067-93-1
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分子量 303.32
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分子式 C15H14NO2PS
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SMILES
N#CC1=CC=C(OP(=S)(OCC)C=2C=CC=CC2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cyanofenphos 関連分類
HY-120131 関連分類
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