D-フェニルアラニン
Based on 1 Customer Validation
D-Phenylalanine is an atypical D-amino acid and an inhibitor of bacterial biofilm formation. D-Phenylalanine mainly replaces D-alanine (D-Ala) by incorporating into the fourth and fifth positions of bacterial peptidoglycan (PG), changing the cell wall structure, enhancing bacterial acid resistance and affecting biofilm formation. D-Phenylalanine may promote the secretion of peptide tyrosine tyrosine (PYY) in mammals by activating the intestinal GPR109B receptor. D-Phenylalanine can inhibit the maturation of microbial biofilms and promote the release of specific hormones. It can be used for antibacterial preservation, improving the yield of probiotics in the food industry, and studying appetite regulation and blood sugar control in metabolic diseases such as diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 673-06-3
- 分子式: C9H11NO2
- 分子量:165.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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溶剤 & 溶解度
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
D-Phenylalanine (50 mM; 1.5 h, 2 h) improves the survival rate of Lactococcus lactis F44 at pH 3.0[1].
D-Phenylalanine (50 mM; 6 h, 8 h, 10 h) increases the production of Nisin (HY-P1607) in Lactococcus lactis F44[1].
D-Phenylalanine (10 mM; 2-10 days) inhibits the maturation of multilayer biofilms of the marine microorganism Pseudoalteromonas sp. SC2014, reduces the number of attached cells, and promotes the decomposition of the formed multilayer biofilm into a monolayer structure, but does not affect the viability of planktonic cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Lactococcus lactis F44
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Concentration:50 mM
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Incubation Time:1.5 h, 2 h
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Result:Increased the survival rate of L. lactis F44 at pH 3.0 by 58.33% and 79.53% after 1.5 h and 2 h of acid shock, respectively.
化学情報
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CAS 番号 673-06-3
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性状 Solid
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分子量 165.19
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分子式 C9H11NO2
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Color White to off-white
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SMILES
N[C@H](CC1=CC=CC=C1)C(O)=O
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別名
D-Phenylalanine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
H2O : 4.17 mg/mL (25.24 mM; Need ultrasonic)
DMSO : 1 mg/mL (6.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (12.11 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
純度とドキュメンテーション
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Wu H, et al. d-Methionine and d-Phenylalanine Improve Lactococcus lactis F44 Acid Resistance and Nisin Yield by Governing Cell Wall Remodeling. Appl Environ Microbiol. 2020 Apr 17;86(9):e02981-19. [Content Brief]
[2]. Li E, et al. D-Phenylalanine inhibits biofilm development of a marine microbe, Pseudoalteromonas sp. SC2014. FEMS Microbiol Lett. 2016 Sep;363(18). [Content Brief]
[3]. Amin A, et al. Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study. Diabetes Obes Metab. 2021 Jan;23(1):147-157. [Content Brief]
[4]. Walsh NE, et al. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil. 1986 Jul;67(7):436-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.0536 mL | 30.2682 mL | 60.5364 mL | 151.3409 mL |
| 5 mM | 1.2107 mL | 6.0536 mL | 12.1073 mL | 30.2682 mL | |
| H2O | 10 mM | 0.6054 mL | 3.0268 mL | 6.0536 mL | 15.1341 mL |
| 15 mM | 0.4036 mL | 2.0179 mL | 4.0358 mL | 10.0894 mL | |
| 20 mM | 0.3027 mL | 1.5134 mL | 3.0268 mL | 7.5670 mL | |
| 25 mM | 0.2421 mL | 1.2107 mL | 2.4215 mL | 6.0536 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Phenylalanine 関連分類
HY-Y0079 関連分類
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