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製品番号: HY-187697

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DB1255

DB1255 is an ERG inhibitor that binds to the minor groove of DNA, with K_D values of 26 nM and 86 nM for the ATGA and AATT sequences, respectively. DB1255 targets and binds to specific DNA minor grooves (single GC/AT-rich sequences), forming a hydrogen bond network with G bases and AT pairs via its thiophene group and amidino group, respectively, thereby blocking the binding of transcription factors. DB1255 can be used in the research of leukemia and prostate cancer.

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CAS 番号: 915978-94-8
分子式: C₂₂H₁₈N₄S₂
分子量:402.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DB1255 構造式

CAS 番号: 915978-94-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

DB1255 (0.25-1.5 μM; 15 min) strongly and specifically binds to the minor groove of DNA and protects DNA fragments with a 265 bp 3'-end label from DNase I digestion^[1].

DB1255 (at DNA molar ratios of 1:1 and 2:1) significantly increases the Tm and stabilizes the DNA double strand in a system containing 3 μM DNA hairpin oligonucleotide duplex^[1].
At a molar ratio of DB1255 to DNA ranging from 0.25 to 2.0 (monitored in real time), DB1255 induces a strong positive circular dichroism signal and exhibits a 1:1 monomer binding mode in a DNA hairpin duplex (3 μM) system^[1].
DB1255 (0.001-0.3 μM) exerts high-affinity monomer binding in a surface plasmon resonance biosensor system immobilized with 5'-biotinylated DNA, with K_D values of 26 nM and 86 nM for sequences containing ATGA and AATT, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

CAS 番号 915978-94-8
分子量 402.53
分子式 C₂₂H₁₈N₄S₂
SMILES

N=C(N)C=1C=CC(=CC1)C=2SC(=CC2)C=3SC(=CC3)C=4C=CC(=CC4)C(=N)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Munde M, et al. The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry. 2014 Feb 25;53(7):1218-27.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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