DC-BPi-11
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2758411-61-7
- 分子式: C20H23N5O2S
- 分子量:397.49
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
SWI/SNF Complex アイソフォーム固有の製品をすべて表示
More
生物活性
698 nM (BPTF)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.89 μM
Compound: DC-BPi-11
|
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
|
[PMID: 34375106] |
DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].
DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].
DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].
DC-BPi-11 is safety and shows minimal effects on normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human leukemia MV-4-11 cells
-
Concentration:0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM
-
Incubation Time:24 hours
-
Result:Resulted depletion of c-Myc in a dose-dependent manner.
-
Cell Line:Human leukemia MV-4-11 cells
-
Concentration:5 μM, 10 μM, 20 μM
-
Incubation Time:24 hours
-
Result:Induced cell apoptosis by arresting cell cycle at G1 phase.
化学情報
-
CAS 番号 2758411-61-7
-
分子量 397.49
-
分子式 C20H23N5O2S
-
SMILES
CN(C)CCCN1C=CC2=C1C=CC(C3=NC(S(C)(=O)=O)=NC4=C3C=CN4)=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DC-BPi-11 関連分類
HY-141703 関連分類
Powered by Bioz