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United States

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製品番号: HY-123517A

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DC07090

DC07090 is a potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC₅₀ and a K_i value for 21.72 μM and 23.29 μM. DC07090 could also inhibit coxsackievirus A16 (CVA16) replication with an EC₅₀ value of 27.76 μM.

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CAS 番号: 879070-72-1
分子式: C₁₈H₁₄N₄O
分子量:302.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DC07090 構造式

CAS 番号: 879070-72-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

IC50: 21.72 μM (EV71 3C protease)^[1].
Ki: 23.29 μM (EV71 3C protease)^[1].
EC50: 27.76 μM (coxsackievirus A16)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
RD	CC₅₀	>200 μM Compound: DC07090	Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay	[PMID: 27776325]

体外実験

DC07090 forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 exhibits a highly inhibitory potency on EV71 replication with an EC₅₀ value of 22.09 μM. DC07090 inhibits CVA16 with an EC₅₀ value of 27.76 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 879070-72-1
分子量 302.33
分子式 C₁₈H₁₄N₄O
SMILES

C1(C(C=C2)=CC=C2NCC3=NC=CC=C3)=NC(N=CC=C4)=C4O1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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