DCP-Bio1
DCP-Bio1 is a targeting labeling reagent for cysteine sulfenic acid (cysteine sulfenic acid). DCP-Bio1 labels protein cysteine sulfenic acid in intact cells via in situ labeling, and also labels cellular proteins during cell lysis. DCP-Bio1 detects sulfenic acid modifications of FLT3 and FLT3ITD in cancer cells. DCP-Bio1 is applicable to research related to sulfenic acid labeling
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 882853-94-3
- 分子式: C19H28N2O5S
- 分子量:396.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
DCP-Bio1 (1 mM; variable times) incorporates into sulfenic acid-containing papaya papain, Escherichia coli C84,94S fRMsr, and Salmonella typhimurium C165S AhpC with distinct first-order rates of 1.65 min−1, 0.13 min−1, and 0.003 min−1, respectively[1].
DCP-Bio1 (0.1-5 mM) incorporation into sulfenic acid-containing proteins in HEK293 cell lysates increases with decreasing protein concentration and increasing DCP-Bio1 concentration, with no difference observed between tumor necrosis factor alpha-treated and untreated cells[1].
DCP-Bio1 (1 mM; 2 h) labels sulfenic acid residues on wild-type FLT3 in RS4-11 cells and FLT3ITD in MV4-11 and HEK293 cells, with cysteines 695 and 790 of FLT3ITD contributing significantly to the labeling signal[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 882853-94-3
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分子量 396.50
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分子式 C19H28N2O5S
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SMILES
O=C(CC(CC1)=O)C1CCCOC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Klomsiri C, et al.. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods in enzymology. 2010;473:77-94. [Content Brief]
[2]. Böhmer A, et al.. Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation. Redox biology. 2020 Jan;28:101325. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DCP-Bio1 関連分類
HY-D3473 関連分類
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