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製品番号: HY-P5062

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DEC-RVRK-CMK

Name: DEC-RVRK-CMK
Brand: MedChemExpress
SKU: HY-P5062
Availability: PreOrder

(別名: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone)

DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK inhibits PC4-mediated proteolysis with an IC₅₀ of 12.2 nM in rats. DEC-RVRK-CMK holds promise for antiviral infection-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 534615-50-4
分子式: C₃₄H₆₆ClN₁₁O₅
分子量:744.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DEC-RVRK-CMK 構造式

CAS 番号: 534615-50-4

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Other In-stock Forms of DEC-RVRK-CMK

DEC-RVRK-CMK TFA

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

OthersProtein/Amino Acid Metabolism

Others

DEC-RVRK-CMK has no inhibitory effect on the cleavage conversion of ADAM2 protein from 46 kDa to 27 kDa during sperm capacitation, whereas the broad-spectrum kexin-like convertase inhibitor dec-RVKR-CMK (HY-107760) can block this processing, indicating that this cleavage is mediated by other members of the PCSK family such as PCSK7 and is independent of PCSK4^[1].
DEC-RVRK-CMK (RVRK) (10 μM; 24-48 h) does not inhibit branching morphogenesis of E15 rat SMG rudiments in organ culture or reduce AQP5 expression^[4].

Protein/Amino Acid Metabolism

DEC-RVRK-CMK (1 h) blocks proconvertase-mediated cleavage of inhibin α- and βB-subunits in LβT2 pituitary gonadotrope cells, leading to accumulation of unprocessed pro-αN-αC and pro-βB^[2].
DEC-RVRK-CMK inhibits purified recombinant rat PC4 (rec-rPC4-FLV5 E1-pool) with an IC₅₀ of 12.2 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 534615-50-4
分子量 744.41
分子式 C₃₄H₆₆ClN₁₁O₅
別名

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
配列

{DEC}-Arg-Val-Arg-Lys-{CMK}
シーケンスの短縮

{DEC}-RVRK-{CMK}
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gyamera-Acheampong C, et al. PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Fertility and sterility. 2010 Mar 01;93(4):1112-23.

[2]. Antenos M, et al. An activin/furin regulatory loop modulates the processing and secretion of inhibin α-and βB-subunit dimers in pituitary gonadotrope cells. Journal of Biological Chemistry. 2008 Nov 28;283(48):33059-68.

[3]. Basak A, et al. Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design. Protein expression and purification. 2008 Aug;60(2):117-26.

[4]. Akamatsu T, et al. Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland. Developmental biology. 2009 Jan 15;325(2):434-43.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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