Dehydroleucodine
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 36150-07-9
- 分子式: C15H16O3
- 分子量:244.29
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa S3 | IC50 |
10 μM
Compound: 1
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Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
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[PMID: 27057812] |
| KB | IC50 |
5.3 μM
Compound: 1
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Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay
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[PMID: 27057812] |
| MCF7 | IC50 |
5 μM
Compound: 1
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Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
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[PMID: 27057812] |
化学情報
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CAS 番号 36150-07-9
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性状 Solid
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分子量 244.29
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分子式 C15H16O3
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Color White to off-white
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SMILES
O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3C(C=C(C)[C@@]31[H])=O)C2=C
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6. [Content Brief]
[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803. [Content Brief]
[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dehydroleucodine 関連分類
HY-122295 関連分類
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