DHC-286
Based on 1 Customer Validation
DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.00%
- CAS 番号: 2920443-08-7
- 分子式: C23H20F3N3O5
- 分子量:475.42
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Eukaryotic Release Factor (eRF) アイソフォーム固有の製品をすべて表示
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生物活性
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eRF3a/GSPT1 |
化学情報
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CAS 番号 2920443-08-7
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性状 Solid
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分子量 475.42
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分子式 C23H20F3N3O5
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Color White to off-white
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SMILES
O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (52.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (310 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1034 mL | 10.5170 mL | 21.0340 mL | 52.5851 mL |
| 5 mM | 0.4207 mL | 2.1034 mL | 4.2068 mL | 10.5170 mL | |
| 10 mM | 0.2103 mL | 1.0517 mL | 2.1034 mL | 5.2585 mL | |
| 15 mM | 0.1402 mL | 0.7011 mL | 1.4023 mL | 3.5057 mL | |
| 20 mM | 0.1052 mL | 0.5259 mL | 1.0517 mL | 2.6293 mL | |
| 25 mM | 0.0841 mL | 0.4207 mL | 0.8414 mL | 2.1034 mL | |
| 30 mM | 0.0701 mL | 0.3506 mL | 0.7011 mL | 1.7528 mL | |
| 40 mM | 0.0526 mL | 0.2629 mL | 0.5259 mL | 1.3146 mL | |
| 50 mM | 0.0421 mL | 0.2103 mL | 0.4207 mL | 1.0517 mL |
DHC-286 関連分類
HY-175334 関連分類
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