Dibenzosuberone
Based on 1 Customer Validation
Dibenzosuberone is a tricyclic compound, commonly referred to as a tricyclic antidepressant (TCA), and is widely used in research on migraine, tension-type headache, anxiety disorder and schizophrenia. Dibenzosuberone also serves as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs) (e.g., amitriptyline (HY-B0527), nortriptyline (HY-118620), nortriptyline or cyproheptadine (HY-B1622)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.84%
- CAS 番号: 1210-35-1
- 分子式: C15H12O
- 分子量:208.26
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF1 (female)[2]
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Dosage:50 mg/kg
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Administration:i.p.; daily; 28 days
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Result:Reduced pregnancy rate to 50% relative to controls.
Achieved 65% viable fetuses per litter relative to controls.
Resulted in 0% absolute reabsorptions per litter (0% relative to controls).
Caused 25% death rate in treated females.
化学情報
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CAS 番号 1210-35-1
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性状 <32°C Solid,>34°C Liquid
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分子量 208.26
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分子式 C15H12O
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Color Colorless to light yellow
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SMILES
O=C1C2=CC=CC=C2CCC3=CC=CC=C13
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (480.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (291 KB)
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SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Hall IH, et al. Cycloalkanones. 4. Antifertility activity. J Med Chem. 1974 Dec;17(12):1253-7.
[3]. Duarte FS, et al. Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):368-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8017 mL | 24.0085 mL | 48.0169 mL | 120.0423 mL |
| 5 mM | 0.9603 mL | 4.8017 mL | 9.6034 mL | 24.0085 mL | |
| 10 mM | 0.4802 mL | 2.4008 mL | 4.8017 mL | 12.0042 mL | |
| 15 mM | 0.3201 mL | 1.6006 mL | 3.2011 mL | 8.0028 mL | |
| 20 mM | 0.2401 mL | 1.2004 mL | 2.4008 mL | 6.0021 mL | |
| 25 mM | 0.1921 mL | 0.9603 mL | 1.9207 mL | 4.8017 mL | |
| 30 mM | 0.1601 mL | 0.8003 mL | 1.6006 mL | 4.0014 mL | |
| 40 mM | 0.1200 mL | 0.6002 mL | 1.2004 mL | 3.0011 mL | |
| 50 mM | 0.0960 mL | 0.4802 mL | 0.9603 mL | 2.4008 mL | |
| 60 mM | 0.0800 mL | 0.4001 mL | 0.8003 mL | 2.0007 mL | |
| 80 mM | 0.0600 mL | 0.3001 mL | 0.6002 mL | 1.5005 mL | |
| 100 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL | 1.2004 mL |
Dibenzosuberone 関連分類
HY-78509 関連分類
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