Didemnin B
Based on 1 publication(s) in Google Scholar
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 77327-05-0
- 分子式: C57H89N7O15
- 分子量:1112.35
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Didemnin B
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
| HT-29 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
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[PMID: 33592144] |
| P388 | IC50 |
>1 μM
Compound: 27
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Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
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[PMID: 33592144] |
| P388 | IC50 |
0.1 μM
Compound: 27
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Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
|
[PMID: 33592144] |
| P388 | IC50 |
0.4 μM
Compound: 27
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Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
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[PMID: 33592144] |
| P388 | IC50 |
2 nM
Compound: 27
|
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
|
[PMID: 33592144] |
| SK-MEL-28 | IC50 |
2 nM
Compound: 27
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Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
|
[PMID: 33592144] |
Didemnin B has activity against miirine B16 melanoma, P388 leukemia, and M5076 sarcoma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 77327-05-0
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性状 Solid
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分子量 1112.35
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分子式 C57H89N7O15
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Color White to off-white
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SMILES
O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C([C@@H](O)C)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O
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配列
{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-Thr-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-Leu-Pro-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
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シーケンスの短縮
{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-T-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-LP-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 100 mg/mL (89.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (287 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Portuguese - PT (537 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Stewart JA, et al. A phase I clinical trial of didemnin B. Cancer. 1991;68(12):2550-2554. [Content Brief]
[2]. Li LH, Timmins LG, Wallace TL, Krueger WC, Prairie MD, Im WB. Mechanism of action of didemnin B, a depsipeptide from the sea. Cancer Lett. 1984;23(3):279-288. [Content Brief]
[3]. Grubb DR, Wolvetang EJ, Lawen A. Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described. Biochem Biophys Res Commun. 1995;215(3):1130-1136. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8990 mL | 4.4950 mL | 8.9900 mL | 22.4749 mL |
| 5 mM | 0.1798 mL | 0.8990 mL | 1.7980 mL | 4.4950 mL | |
| 10 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL | 2.2475 mL | |
| 15 mM | 0.0599 mL | 0.2997 mL | 0.5993 mL | 1.4983 mL | |
| 20 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1237 mL | |
| 25 mM | 0.0360 mL | 0.1798 mL | 0.3596 mL | 0.8990 mL | |
| 30 mM | 0.0300 mL | 0.1498 mL | 0.2997 mL | 0.7492 mL | |
| 40 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5619 mL | |
| 50 mM | 0.0180 mL | 0.0899 mL | 0.1798 mL | 0.4495 mL | |
| 60 mM | 0.0150 mL | 0.0749 mL | 0.1498 mL | 0.3746 mL | |
| 80 mM | 0.0112 mL | 0.0562 mL | 0.1124 mL | 0.2809 mL |
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