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製品番号: HY-106470

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Difenamizole

Name: Difenamizole
Brand: MedChemExpress
SKU: HY-106470
Availability: PreOrder

(別名: Pasalin)

Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine (HY-B0431), Reserpine (HY-N0480), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 20170-20-1
分子式: C₂₀H₂₂N₄O
分子量:334.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (292 KB)

Difenamizole 構造式

CAS 番号: 20170-20-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Dopamine Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

Difenamizole (25-150 mg/kg; p.o.; single dose) alters cerebral catecholamine and metabolite levels in healthy male ddY mice, including dose-dependent increases in dien-+mesencephalic NE and significant decreases in striatal 3-MT and dien-+mesencephalic NM^[1].
Difenamizole (50 mg/kg; p.o.; single dose) significantly reduces striatal 3-MT and HVA concentrations 60 minutes post-administration in healthy male ddY mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 20-22 g)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; single dose
Result:

Increased striatal dopamine levels to 4735.2 ng/g wet weight.
Decreased striatal 3-MT levels to 218.8 ng/g wet weight.
Decreased striatal homovanillic acid (HVA) levels to 461.0 ng/g wet weight.

Related Protocols :

Research Protocol for Inflammation-related Diseases

化学情報

CAS 番号 20170-20-1
分子量 334.42
分子式 C₂₀H₂₂N₄O
SMILES

O=C(NC1=CC(=NN1C=2C=CC=CC2)C=3C=CC=CC3)C(N(C)C)C
別名

Pasalin
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (292 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nabeshima T, et al. Effects of difenamizole on content of catecholamines and metabolites in mouse brain[J]. The Japanese Journal of Pharmacology, 1978, 28(4): 642-646.

[2]. Saleem BAA, et al.. Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity. RSC advances. 2026 Jun 02;16(33):30052-30069. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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