Difludiazepam
Difludiazepam (Ro 07-4065), a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 39080-67-6
- 分子式: C16H11ClF2N2O
- 分子量:320.72
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
GABAA Receptor[1]
Difludiazepam exhibits a predicted GABAA receptor binding affinity (log 1/c = 9.16) that is greater than the previously reported highest predicted binding affinity for designer benzodiazepines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 39080-67-6
-
性状 Solid
-
分子量 320.72
-
分子式 C16H11ClF2N2O
-
Color White to off-white
-
SMILES
ClC1=CC(C(C2=C(C=CC=C2F)F)=NCC3=O)=C(N3C)C=C1
-
別名
Ro 07-4065
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMF : 15 mg/mL (46.77 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (288 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Manchester KR, et al. The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. Forensic Toxicol. 2022 Jul;40(2):349-356. [Content Brief]
[2]. So SS, et al. Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem. 1996 Dec 20;39(26):5246-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 3.1180 mL | 15.5899 mL | 31.1798 mL | 77.9496 mL |
| 5 mM | 0.6236 mL | 3.1180 mL | 6.2360 mL | 15.5899 mL | |
| 10 mM | 0.3118 mL | 1.5590 mL | 3.1180 mL | 7.7950 mL | |
| 15 mM | 0.2079 mL | 1.0393 mL | 2.0787 mL | 5.1966 mL | |
| 20 mM | 0.1559 mL | 0.7795 mL | 1.5590 mL | 3.8975 mL | |
| 25 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1180 mL | |
| 30 mM | 0.1039 mL | 0.5197 mL | 1.0393 mL | 2.5983 mL | |
| 40 mM | 0.0779 mL | 0.3897 mL | 0.7795 mL | 1.9487 mL |
Difludiazepam 関連分類
HY-124467 関連分類
Powered by Bioz