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製品番号: HY-N19799

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Diorcinol D

Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candida albicans. Diorcinol D is applicable to research related to fungal infections.

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CAS 番号: 1464778-45-7
分子式: C₁₉H₂₂O₃
分子量:298.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Diorcinol D 構造式

CAS 番号: 1464778-45-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Diorcinol D inhibits planktonic growth of wild-type, Fluconazole (HY-B0101)-sensitive, Fluconazole-resistant and efflux pump-mutant Candida albicans strains, with an MIC range of 6 μg/mL to 16 μg/mL. Notably, the CDR1-deficient mutant shows increased sensitivity (MIC = 6 μg/mL)^[1].
Diorcinol D (24 h) inhibits the growth of mature biofilms formed by wild-type, fluconazole-sensitive and fluconazole-resistant Candida albicans strains, with an MIC of 32 μg/mL^[1].
Diorcinol D (8-32 μg/mL; 48 h) significantly increases cell death in mature Candida albicans YEM30 biofilms at the concentration of 32 μg/mL^[1].
Diorcinol D (4-12 μg/mL; 30 min) dose-dependently inhibits ATP-driven Rh123 efflux in both fluconazole-sensitive Candida albicans strain 18B and fluconazole-resistant strain 28I^[1].
Diorcinol D (4-12 μg/mL; 3 h) reduces the expression of CDR1 in Candida albicans CASA1 in a dose-dependent manner^[1].
Diorcinol D (4-12 μg/mL; 3 h) dose-dependently reduces ergosterol biosynthesis in Fluconazole-susceptible Candida albicans strain 18B and Fluconazole-resistant strain 28I, with a reduction range of 6.1% to 37.2%^[1].
Diorcinol D (8 μg/mL; 3 h) reduces the CYP51 gene expression level by 2.8-fold in Fluconazole-susceptible Candida albicans strain 18B, and by 1.8-fold in Fluconazole-resistant Candida albicans strain 28I^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

Candida albicans CASA1
Concentration:

4, 8, and 12 μg/mL
Incubation Time:

3 h
Result:

Significant decreaseD in GFP fluorescence.

化学情報

CAS 番号 1464778-45-7
分子量 298.38
分子式 C₁₉H₂₂O₃
SMILES

CC1=CC(OC2=CC(O)=CC(C)=C2C/C=C(C)/C)=CC(O)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
endophytic fungus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Li Y, et al. Synergistic and drug-resistant reversing effects of diorcinol D combined with fluconazole against Candida albicans. FEMS Yeast Res. 2015;15(2):fov001. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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