Diprotin A
Based on 4 publication(s) in Google Scholar
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
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- 純度 : 99.90%
- CAS 番号: 90614-48-5
- 分子式: C17H31N3O4
- 分子量:341.45
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保管条件:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Diprotin A
More
生物活性
製品説明
IC50 & Target
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DPP-4 |
体外実験
Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human endothelial cells[1]
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Concentration:100 μM
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Incubation Time:30 minutes after CXCR4-blocker or Src-inhibitor treatment
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Result:Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice[1]
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Dosage:70 μg/kg
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Administration:Intraperitoneal injection; twice daily; 7 days
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Result:Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
化学情報
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CAS 番号 90614-48-5
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性状 Solid
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分子量 341.45
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分子式 C17H31N3O4
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Color White to off-white
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別名
Ile-Pro-Ile; ジプロチン
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配列
Ile-Pro-Ile
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シーケンスの短縮
IPI
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Phytomedicine
Large-leaf yellow tea oligosaccharides alleviate T2DM by promoting GLP-1 secretion and regulating intestinal mucosal barrier. [Abstract]2026 Jun:155:158079. PMID: 41861686 -
Cell Rep
Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation. [Abstract]2025 Jan 25;44(2):115241. PMID: 39864058 -
Pharm Res
Liposomal Vardenafil and Linagliptin Combined with Irinotecan for Synergistic Colorectal Cancer Therapy. [Abstract]2025 Jun;42(6):935-945. PMID: 40473893
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (292.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (292.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (295 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.9287 mL | 14.6434 mL | 29.2869 mL | 73.2172 mL |
| 5 mM | 0.5857 mL | 2.9287 mL | 5.8574 mL | 14.6434 mL | |
| 10 mM | 0.2929 mL | 1.4643 mL | 2.9287 mL | 7.3217 mL | |
| 15 mM | 0.1952 mL | 0.9762 mL | 1.9525 mL | 4.8811 mL | |
| 20 mM | 0.1464 mL | 0.7322 mL | 1.4643 mL | 3.6609 mL | |
| 25 mM | 0.1171 mL | 0.5857 mL | 1.1715 mL | 2.9287 mL | |
| 30 mM | 0.0976 mL | 0.4881 mL | 0.9762 mL | 2.4406 mL | |
| 40 mM | 0.0732 mL | 0.3661 mL | 0.7322 mL | 1.8304 mL | |
| 50 mM | 0.0586 mL | 0.2929 mL | 0.5857 mL | 1.4643 mL | |
| 60 mM | 0.0488 mL | 0.2441 mL | 0.4881 mL | 1.2203 mL | |
| 80 mM | 0.0366 mL | 0.1830 mL | 0.3661 mL | 0.9152 mL | |
| 100 mM | 0.0293 mL | 0.1464 mL | 0.2929 mL | 0.7322 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Diprotin A 関連分類
HY-111174 関連分類
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