Disoxaril
Based on 1 Customer Validation
Disoxaril (WIN-51711) is an antivirus agent with activity against poliovirus types 1 and 2. Disoxaril inserts into the hydrophobic interior of virus capsid protein VP1 to stabilize virion conformation, inhibits poliovirus uncoating, and prevents viral RNA release and synthesis. Disoxaril can be used for the research of poliovirus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.50%
- CAS 番号: 87495-31-6
- 分子式: C20H26N2O3
- 分子量:342.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | CC50 |
21 μM
Compound: Disoxaril
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Antiviral activity against Human rhinovirus type 14 in human HeLa Ohio-1 cells
Antiviral activity against Human rhinovirus type 14 in human HeLa Ohio-1 cells
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[PMID: 18590964] |
| HeLa | CC50 |
37 μM
Compound: WIN-51711
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Compound concentration required to reduce the viability of mock-infected HeLa cells by 50%, was reported.
Compound concentration required to reduce the viability of mock-infected HeLa cells by 50%, was reported.
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[PMID: 7877145] |
| HeLa | EC50 |
1.76 μM
Compound: WIN-51711
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In vitro concentration required to achieve 50% protection of HeLa cells from HRV-14 induced cytopathic effect
In vitro concentration required to achieve 50% protection of HeLa cells from HRV-14 induced cytopathic effect
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[PMID: 7877145] |
| HeLa | EC50 |
2.35 μM
Compound: WIN-51711
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In vitro concentration required to achieve 50% protection of HeLa cells from HRV-2 induced cytopathic effect
In vitro concentration required to achieve 50% protection of HeLa cells from HRV-2 induced cytopathic effect
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[PMID: 7877145] |
| HeLa | IC50 |
1.5 μM
Compound: Disoxaril
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Cytotoxicity against human HeLa Ohio-1 cells
Cytotoxicity against human HeLa Ohio-1 cells
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[PMID: 18590964] |
| RD | CC50 |
167.39 μM
Compound: 5; WIN 51711
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Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
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[PMID: 26885567] |
| RD | EC50 |
15.32 μM
Compound: 5; WIN 51711
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Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
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[PMID: 26885567] |
| Vero | CC50 |
147.77 μM
Compound: 5; WIN 51711
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Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
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[PMID: 26885567] |
| Vero | EC50 |
19.48 μM
Compound: 5; WIN 51711
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Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
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[PMID: 26885567] |
Disoxaril (35-140 μM; 48 h) inhibits FL cell growth with a CGIC50 of 70 μM[1].
Disoxaril (0.03-0.3 μg/mL; 15 min preincubation) inhibits replication of poliovirus type 1 and type 2 in HeLa cells by stabilizing the virus capsid to block pH-dependent viral uncoating in endosomes and/or lysosomes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FL cells
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Concentration:2xCGIC50, 1xCGIC50, CGIC50/2, CGIC50/4, CGIC50/8 (CGIC50 = 70 μmol/l)
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Incubation Time:48 h
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Result:Reduced viable cell number to 27.70% of control at 2xCGIC50, 45.55% at 1xCGIC50, 50.06% at CGIC50/2, 59.04% at CGIC50/4, and 68.50% at CGIC50/8.
Achieved a CGIC50 of 70 μmol/l for FL cell growth inhibition.
Yielded a selectivity index (SI = IC50/CGIC50) of 233.3, with an IC50 of 0.3 μmol/l for poliovirus type 1 replication inhibition.
Showed additive or sub-additive cytotoxic effects when combined with enviroxime, with no synergistic cytotoxicity detected.
化学情報
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CAS 番号 87495-31-6
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性状 Solid
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分子量 342.43
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分子式 C20H26N2O3
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Color White to off-white
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SMILES
CC1=NOC(CCCCCCCOC2=CC=C(C3=NCCO3)C=C2)=C1
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別名
WIN-51711
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 3.33 mg/mL (9.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9203 mL | 14.6015 mL | 29.2030 mL | 73.0076 mL |
| 5 mM | 0.5841 mL | 2.9203 mL | 5.8406 mL | 14.6015 mL |
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