DL-Tryptophan
Based on 1 Customer Validation
DL-Tryptophan ((±)-Tryptophan) is an orally effective aryl hydrocarbon receptor (AhR) agonist. DL-Tryptophan reduces the expression of pro-inflammatory cytokines IL-6, TNF-α, IL-1β, as well as liver injury markers aspartate aminotransferase and alanine aminotransferase, and alleviates hepatocyte apoptosis (apoptosis) in sepsis induced by cecal ligation and puncture. DL-Tryptophan can be used in the research of sepsis-related acute liver injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 54-12-6
- 分子式: C11H12N2O2
- 分子量:204.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-N0623
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L-Tryptophan (standard)
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HY-W012480R
DL-Tryptophan (Standard)
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
IL-6 |
IL-1β |
DL-Tryptophan binds tightly to purified AhR protein via multiple molecular interactions, with a reaction free energy of -8.129 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (8-week-old male or female, 20-25 g; CLP surgery-induced sepsis)[1]
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Dosage:200 mg/kg
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Administration:p.o.; daily; 7 consecutive days
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Result:Significantly reduced hepatic mRNA expression of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β
Decreased serum levels of liver damage markers AST and ALT.
Mitigated liver lobular structure destruction, edema, and inflammatory cell infiltration compared to the CLP group.
Reduced F4/80+ macrophage infiltration and hepatocyte apoptosis in liver tissue.
Restored hepatic expression of AhR/GAPDH and CYP1A1/GAPDH to levels not significantly different from sham-operated mice.
化学情報
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CAS 番号 54-12-6
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性状 Solid
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分子量 204.23
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分子式 C11H12N2O2
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Color White to light yellow
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SMILES
NC(CC1=CNC2=CC=CC=C12)C(O)=O
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別名
(±)-Tryptophan
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 2.86 mg/mL (14.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8964 mL | 24.4822 mL | 48.9644 mL | 122.4110 mL |
| 5 mM | 0.9793 mL | 4.8964 mL | 9.7929 mL | 24.4822 mL | |
| 10 mM | 0.4896 mL | 2.4482 mL | 4.8964 mL | 12.2411 mL |
DL-Tryptophan 関連分類
HY-W012480 関連分類
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- DL-Tryptophan
- 54-12-6
- (±)-Tryptophan
- Endogenous Metabolite
- Aryl Hydrocarbon Receptor
- Interleukin Related
- TNF Receptor
- Apoptosis
- macrophage infiltration
- inflammatory cell infiltration
- AhR
- sepsis-related acute liver injury
- pro-inflammatory cytokine
- aryl hydrocarbon receptor
- liver lobular architecture
- CLP-induced sepsis-related acute liver injury
- hepatocyte apoptosis
- Inhibitor
- inhibitor
- inhibit