(-)-DMNP
(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C17H24O2
- 分子量:260.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
(-)-DMNP (1.06 mM; 0-48 h) potently reduces persister cell survival in stationary-phase Mycobacterium smegmatis mc2 155 cells, with greater activity than racemic DMNP and no activity observed from the (+)-DMNP enantiomer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Mycobacterium smegmatis mc2 155 wild-type strain
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Concentration:1.06 mM
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Incubation Time:0-48 h
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Result:Reduced survivor cell numbers in stationary-phase cells, with survival declining to near undetectable levels by 24 h.
Exhibited slightly greater activity than racemic DMNP mixture.
Showed far greater activity than (+)-DMNP, which had no noticeable antipersister activity.
化学情報
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分子量 260.37
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分子式 C17H24O2
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SMILES
C[C@@H]1CC[C@]([C@H](C)CCC(O)=O)([H])C2=CC(C)=CC=C21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(-)-DMNP 関連分類
HY-186290 関連分類
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