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United States

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製品番号: HY-186290

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(-)-DMNP

(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₇H₂₄O₂
分子量:260.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-DMNP 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Bacterial Infection

(-)-DMNP (1.06 mM; 0-48 h) potently reduces persister cell survival in stationary-phase Mycobacterium smegmatis mc² 155 cells, with greater activity than racemic DMNP and no activity observed from the (+)-DMNP enantiomer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Mycobacterium smegmatis mc² 155 wild-type strain
Concentration:

1.06 mM
Incubation Time:

0-48 h
Result:

Reduced survivor cell numbers in stationary-phase cells, with survival declining to near undetectable levels by 24 h.
Exhibited slightly greater activity than racemic DMNP mixture.
Showed far greater activity than (+)-DMNP, which had no noticeable antipersister activity.

化学情報

分子量 260.37
分子式 C₁₇H₂₄O₂
SMILES

C[C@@H]1CC[C@]([C@H](C)CCC(O)=O)([H])C2=CC(C)=CC=C21
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Tkachenko AG, et al. A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases. Cell chemical biology. 2021 Oct 21;28(10):1420-1432.e9.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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