DOPE-PEG2000-GRGDS

DOPE-PEG2000-GRGDS: surface functionalization of liposomes and nanoparticles for integrin receptor-targeted drug delivery to tumors and angiogenic vasculature, applicable in cancer therapy and anti-angiogenic treatment.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-dependent membrane fusion for intracellular drug release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces protein adsorption and immune clearance, and prolongs circulation half-life;
(3) GRGDS peptide; an RGD-containing peptide that specifically binds to integrin receptors (alphavbeta3, alphavbeta5) overexpressed on tumor cells and activated endothelial cells, enabling active targeting of tumor tissues and angiogenic vasculature while potentially exerting anti-angiogenic effects by blocking integrin-mediated signaling.

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