DOPE-PEG2000-SP94
DOPE-PEG2000-SP94 (DOPE-PEG2000-Mal-Cys-SP94) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the SP94 peptide (sequence: SFSIIHTPILPL), a hepatocellular carcinoma (HCC) -targeting peptide. DOPE-PEG2000-SP94 is used for HCC-targeted drug delivery through liposome and nanoparticle functionalization.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
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Help & FAQs
生物活性
製品説明
体外実験
DOPE-PEG2000-SP94: surface decoration of liposomes and lipid nanoparticles for hepatocellular carcinoma (HCC) -targeted drug delivery, enabling selective accumulation in liver cancer tissues.
Structural composition:
(1) DOPE; a phospholipid with two unsaturated oleoyl chains that anchors into lipid bilayers and provides fusogenic activity for endosomal escape;
(2) PEG2000; a hydrophilic polymer that forms a stealth layer reducing opsonization and prolonging circulation time;
(3) SP94 peptide; an HCC-specific targeting peptide identified by phage display that specifically binds to receptors on hepatocellular carcinoma cells (not normal hepatocytes), directing nanocarriers to liver cancer tissues for enhanced drug uptake by HCC cells and improved therapeutic efficacy with reduced toxicity to normal liver tissue.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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SMILES
[DOPE-PEG2000-SP94]
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別名
DOPE-PEG2000-Mal-Cys-SP94
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DOPE-PEG2000-SP94 関連分類
HY-187491A 関連分類
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