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製品番号: HY-128576

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DS21360717

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC₅₀ of 0.49 nM. Anti-cancer activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.80%
CAS 番号: 2304654-43-9
分子式: C₂₁H₂₃N₇O
分子量:389.45

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DS21360717 構造式

CAS 番号: 2304654-43-9

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC₅₀ of 0.49 nM. Anti-cancer activity^[1].

EGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	220 nM Compound: 21; DS21360717	Growth inhibition of mouse mock transfected BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay Growth inhibition of mouse mock transfected BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay	[PMID: 31097992]

化学情報

CAS 番号 2304654-43-9
性状 Solid
分子量 389.45
分子式 C₂₁H₂₃N₇O
Color White to light yellow
SMILES

N[C@H]1CCCC[C@H]1NC2=NC(NC3=CC(C)=CC=C3)=C4C(C=NNC4=O)=C2C#N
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Nat Commun

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors. [Abstract]

2025 Aug 23;16(1):7870. PMID: 40849425
Heliyon

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes. [Abstract]

2024 Jun 20;10(13):e33358. PMID: 39035505

溶剤 & 溶解度

体外:

DMSO : 200 mg/mL (513.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5677 mL

12.8386 mL

25.6772 mL

5 mM

0.5135 mL

2.5677 mL

5.1354 mL

10 mM

0.2568 mL

1.2839 mL

2.5677 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Taniguchi T, et al. Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. ACS Med Chem Lett. 2019 Mar 15;10(5):737-742. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5677 mL	12.8386 mL	25.6772 mL	64.1931 mL
	5 mM	0.5135 mL	2.5677 mL	5.1354 mL	12.8386 mL
	10 mM	0.2568 mL	1.2839 mL	2.5677 mL	6.4193 mL
	15 mM	0.1712 mL	0.8559 mL	1.7118 mL	4.2795 mL
	20 mM	0.1284 mL	0.6419 mL	1.2839 mL	3.2097 mL
	25 mM	0.1027 mL	0.5135 mL	1.0271 mL	2.5677 mL
	30 mM	0.0856 mL	0.4280 mL	0.8559 mL	2.1398 mL
	40 mM	0.0642 mL	0.3210 mL	0.6419 mL	1.6048 mL
	50 mM	0.0514 mL	0.2568 mL	0.5135 mL	1.2839 mL
	60 mM	0.0428 mL	0.2140 mL	0.4280 mL	1.0699 mL
	80 mM	0.0321 mL	0.1605 mL	0.3210 mL	0.8024 mL
	100 mM	0.0257 mL	0.1284 mL	0.2568 mL	0.6419 mL

Keywords

DS21360717

2 Cited Publications

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DS21360717

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

MedChemExpress（MCE）の使用を引用している文献 DS21360717

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

DS21360717

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

MedChemExpress（MCE）の使用を引用している文献 DS21360717

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

DS21360717 関連分類

HY-128576 関連分類