DS39201083
DS39201083, a Conolidine derivative, is a potent and orally active analgesic agent. DS39201083 shows no agonist activity at the mu opioid receptor. DS39201083 can be used for the study of neurological diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2361560-81-6
- 分子式: C16H18N2O
- 分子量:254.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
DS39201083 exhibits an IC50 of 71 μM in the mu-opioid receptor (MOR) binding assay; in the functional MOR cAMP assay, it demonstrates an EC50 >100 μM and an Emax of 12%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DS39201083 shows excellent dose-dependent activity in the acetic acid-induced writhing test in Slc:ddY mice (ED50=7.8 mg/kg; 23%, 52%, and 94% inhibition at 3, 10, and 30 mg/kg, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3.5% formalin (20 µL) was injected into the hind paw pad of Slc:ddY mice[1].
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Dosage:30 mg/kg
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Administration:Oral gavage, once, before 3.5% formalin (20 µL) was injected into the hind paw pad.
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Result:Showed a 92% inhibition rate of initial phase pain.
化学情報
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CAS 番号 2361560-81-6
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分子量 254.33
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分子式 C16H18N2O
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SMILES
O=C1C2=C(CN3CCC1(CC3)C)C4=C(C=CC=C4)N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DS39201083 関連分類
HY-128624 関連分類
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