DVD-445
Based on 1 Customer Validation
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.36%
- CAS 番号: 2375846-41-4
- 分子式: C25H28F2N2O4
- 分子量:458.50
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.60 μM (rat TrxR1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
8.3 μM
Compound: 7; DVD-445
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Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31400708] |
| MRC5 | IC50 |
11.85 μM
Compound: DVD-445
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32087464] |
| PBMC | IC50 |
55.71 μM
Compound: 7; DVD-445
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Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31400708] |
| SH-SY5Y | IC50 |
10.99 μM
Compound: 7; DVD-445
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31400708] |
| SH-SY5Y | IC50 |
7.26 μM
Compound: 7; DVD-445
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Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
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[PMID: 31400708] |
| U-87MG ATCC | IC50 |
8.9 μM
Compound: DVD-445
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Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32087464] |
| U-87MG ATCC | IC50 |
9.7 μM
Compound: 7; DVD-445
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Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31400708] |
DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2375846-41-4
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性状 Solid
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分子量 458.50
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分子式 C25H28F2N2O4
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Color White to off-white
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SMILES
O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1810 mL | 10.9051 mL | 21.8103 mL | 54.5256 mL |
| 5 mM | 0.4362 mL | 2.1810 mL | 4.3621 mL | 10.9051 mL | |
| 10 mM | 0.2181 mL | 1.0905 mL | 2.1810 mL | 5.4526 mL | |
| 15 mM | 0.1454 mL | 0.7270 mL | 1.4540 mL | 3.6350 mL | |
| 20 mM | 0.1091 mL | 0.5453 mL | 1.0905 mL | 2.7263 mL | |
| 25 mM | 0.0872 mL | 0.4362 mL | 0.8724 mL | 2.1810 mL | |
| 30 mM | 0.0727 mL | 0.3635 mL | 0.7270 mL | 1.8175 mL | |
| 40 mM | 0.0545 mL | 0.2726 mL | 0.5453 mL | 1.3631 mL | |
| 50 mM | 0.0436 mL | 0.2181 mL | 0.4362 mL | 1.0905 mL | |
| 60 mM | 0.0364 mL | 0.1818 mL | 0.3635 mL | 0.9088 mL | |
| 80 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6816 mL | |
| 100 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5453 mL |
DVD-445 関連分類
HY-126322 関連分類
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