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製品番号: HY-129862A

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Eclanamine

Eclanamine is an orally effective non-tricyclic antidepressant and an adrenergic receptor modulator. Eclanamine blocks biogenic amine uptake and enhances α2-receptor sensitivity, and long-term administration induces downregulation and desensitization of cortical β-receptors. Eclanamine is used in the study of depression.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 67450-44-6
分子式: C₁₆H₂₂Cl₂N₂O
分子量:329.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Eclanamine 構造式

CAS 番号: 67450-44-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
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生物活性

製品説明

IC₅₀ & Target

^[1]

α2-adrenergic receptor

β adrenergic receptor

Adrenergic Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

Eclanamine weakly inhibits the binding of (³H)-dihydroalpranolol (DHA) in rat brain cortex tissue homogenates (inhibition rate below 50%)^[3].
Eclanamine induces gene mutations in CHO/HPRT and AS52 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

Eclanamine (45 mg single dose; p.o.; single administration; urine is monitored and collected for 96 h after administration) produces N-desmethyleclanamine (DME) and N,N-didesmethyleclanamine (DDME) metabolites and is excreted in urine^[1].
Eclanamine (1-30 mg/kg/day; i.v.; continuous infusion; treatment duration of 8 to 168 h) dose-dependently downregulates cerebral cortical β-adrenergic receptor (beta-AR) density in female Sprague-Dawley rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (female, 280-320 g)^[3]
Dosage:

1, 3, 10, and 30 mg/kg/day
Administration:

i.v.; continuous infusion; 24 h
Result:

Dose-dependently reduced the density of beta-adrenergic receptors (Bmax) in the cerebral cortex with a significant dose-response relationship.
The minimum effective dose that significantly down-regulated beta-AR at 24 hours was 3.0 mg/kg/day.

Animal Model:

Sprague-Dawley rats (female)^[3]
Dosage:

10 mg/kg/day
Administration:

i.v.; continuous infusion; 8, 16, 24, 48, 72, and 168 hours
Result:

Resulted in a significant reduction in the number of beta-AR at 16 and 24 hours.
The peak effect was observed at 72 hours, at which time it produced a similar degree of down-regulation to imipramine.

化学情報

CAS 番号 67450-44-6
分子量 329.26
分子式 C₁₆H₂₂Cl₂N₂O
SMILES

CCC(N(C1=CC(Cl)=C(C=C1)Cl)[C@H]2[C@@H](CCC2)N(C)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lakings DB, et al. High-performance liquid chromatographic method for the determination of eclanamine and its N-desmethyl and N,N-didesmethyl metabolites in urine. J Chromatogr. 1988 Jun 24;428(1):131-9.

[2]. Aaron CS, et al. Risk and benefit evaluation in development of pharmaceutical products. Environ Health Perspect.

[3]. Sethy VH, et al. Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. 1988;12(5):673-82.

[4]. Szmuszkovicz J, et al. A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds. J Med Chem. 1981 Oct;24(10):1230-6. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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