Etelcalcetide
Based on 2 publication(s) in Google Scholar
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1262780-97-1
- 分子式: C38H73N21O10S2
- 分子量:1048.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cinacalcet (Standard)CaSR Agonist
MedChemExpress（MCE）の使用を引用している文献 Etelcalcetide
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生物活性
製品説明
体外実験
Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL7/6J male mice
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Dosage:2.5 µg/h and 20 µg/h
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Administration:infusion, 3 days
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Result:Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 µg/h, but decreased the renal expression of Cyp24a1 with 20 µg/h[1]
化学情報
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CAS 番号 1262780-97-1
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分子量 1048.25
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分子式 C38H73N21O10S2
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別名
Velcalcetide; AMG 416; KAI-4169
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配列
Ac-dCys(disulfide bridge:Cys)-d(Ala-Arg-Arg-Arg-Ala-Arg)-NH2
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シーケンスの短縮
Ac-dCys(disulfide bridge:Cys)-d(ARRRAR)-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Commun Biol
Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges. [Abstract]2024 Apr 25;7(1):501. PMID: 38664468 -
J Clin Endocrinol Metab
Heterogenous Origins of Calcium Homeostasis Disorders Arising from Five Heterozygous Calcium-Sensing Receptor Variants. [Abstract]2025 Jun 17;110(7):1865-1880. PMID: 39413244
純度とドキュメンテーション
参考文献
[1]. [1]Van Megen WH, et al. Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1[J]. EBioMedicine. 2022 Apr;78:103947. [Content Brief]
[2]. Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Etelcalcetide 関連分類
HY-P1955 関連分類
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