Evybactin
Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C64H89N21O21
- 分子量:1488.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
IC50: 1 μM (DNA cleavage)[1]
体外実験
Evybactin (0-1000 µg/mL; 24 h) inhibits Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL[1]. Evybactin (100 µM; 30 min) induces DNA cleavage with an IC50 value of 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HepG2, FaDu and HEK293 cell lines
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Concentration:0-1000 µg/mL
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Incubation Time:24 hours
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Result:Showed no toxicity against HepG2, FaDu and HEK293 human cells with IC50s ＞128 µg/mL.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with E. coli infection[1]
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Dosage:25 and 100 mg/kg
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Administration:Intraperitoneal injection; 25 and 100 mg/kg once
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Result:Showed significant efficacy with a single dose of 25 mg/kg, and protected mice from infection with a single dose of 100 mg/kg, whereas 83% of untreated control animals died in 24 hours.
化学情報
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分子量 1488.52
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分子式 C64H89N21O21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Evybactin 関連分類
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