Ezetimibe phenoxy glucuronide
Based on 2 publication(s) in Google Scholar
Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.
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- 純度: 99.77%
- CAS 番号: 190448-57-8
- 分子式: C30H29F2NO9
- 分子量:585.55
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Ezetimibe phenoxy glucuronide
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.3 μM
Compound: 2
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Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human recombinant NPC1L1 e
Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human recombinant NPC1L1 e
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[PMID: 19410454] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 190448-57-8
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性状 Solid
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分子量 585.55
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分子式 C30H29F2NO9
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Color White to pink
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SMILES
O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2
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別名
Ezetimibe glucuronide; Ezetimibe β-D-glucuronide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
2025 Oct 23:117451. PMID: 41138926 -
J Biochem Mol Toxicol
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway. [Abstract]2024 Aug;38(8):e23792. PMID: 39082152
溶剤 & 溶解度
DMSO : 100 mg/mL (170.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [Content Brief]
[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7078 mL | 8.5390 mL | 17.0780 mL | 42.6949 mL |
| 5 mM | 0.3416 mL | 1.7078 mL | 3.4156 mL | 8.5390 mL | |
| 10 mM | 0.1708 mL | 0.8539 mL | 1.7078 mL | 4.2695 mL | |
| 15 mM | 0.1139 mL | 0.5693 mL | 1.1385 mL | 2.8463 mL | |
| 20 mM | 0.0854 mL | 0.4269 mL | 0.8539 mL | 2.1347 mL | |
| 25 mM | 0.0683 mL | 0.3416 mL | 0.6831 mL | 1.7078 mL | |
| 30 mM | 0.0569 mL | 0.2846 mL | 0.5693 mL | 1.4232 mL | |
| 40 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL | 1.0674 mL | |
| 50 mM | 0.0342 mL | 0.1708 mL | 0.3416 mL | 0.8539 mL | |
| 60 mM | 0.0285 mL | 0.1423 mL | 0.2846 mL | 0.7116 mL | |
| 80 mM | 0.0213 mL | 0.1067 mL | 0.2135 mL | 0.5337 mL | |
| 100 mM | 0.0171 mL | 0.0854 mL | 0.1708 mL | 0.4269 mL |
Ezetimibe phenoxy glucuronide 関連分類
HY-135391 関連分類
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