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製品番号: HY-182460

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Gambogin

Gambogin is an α-glucosidase inhibitor, found in the resin and dry latex of Garcinia hanburyi. Gambogin exists as an inseparable diastereomeric pair of C-2 epimers (8a and 8b), with 8a having an α-glucosidase inhibitory IC₅₀ of 209.2 μM and 8b showing α-glucosidase inhibitory IC₅₀ > 300 μM. Gambogin can be used for the research of type 2 diabetes and cervical cancer.

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CAS 番号: 173792-67-1
分子式: C₃₈H₄₆O₆
分子量:598.77

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gambogin 構造式

CAS 番号: 173792-67-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

α‑glucosidase

209.2 μM (IC₅₀)

体外実験

Gambogin (Compound 8) isomer 8a (20 min) modestly inhibits Saccharomyces cerevisiae α-glucosidase with an IC₅₀ of 209.2 μM, while gambogin isomer 8b shows no inhibitory activity at concentrations up to 300 μM^[1].
Gambogin (24 h) potently inhibits the growth of cultured HeLa and HEL #17 cells, with minimum inhibitory concentration values of 6.25 μg/mL and 3.13 μg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 173792-67-1
分子量 598.77
分子式 C₃₈H₄₆O₆
SMILES

O=C1C2=C(O[C@@]3([C@@](C4=O)(C/C=C(C)\C)OC5(C)C)[C@@]5([H])C[C@@]4([H])C=C31)C(C/C=C(C)\C)=C6C(C=CC(CC/C=C(C)/C)(C)O6)=C2O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chen Y, et al. Caged polyprenylated xanthones from the resin of Garcinia hanburyi. Fitoterapia. 2016;109:106-112. [Content Brief]

[2]. Asano J, et al. Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry. 1996;41(3):815-820. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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