RNF41 - ring finger protein 41 Gene

Also Known as FLRF; NRDP1; SBBI03

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10193

About RNF41

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,202,179-56,221,969 (from NCBI)

This gene has 12 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 10.6), prostate (RPKM 9.7) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

RNF41 Products (4)

mRNA Protein Name
NM_001242826.2 NP_001229755.1 E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_005785.4 NP_005776.1 E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_194358.3 NP_919339.1 E3 ubiquitin-protein ligase NRDP1 isoform 2
NM_194359.2 NP_919340.1 E3 ubiquitin-protein ligase NRDP1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
22493164 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11867753 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
27353365 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
27353365 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
18541373 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14765125 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
14765125 GOA
acts upstream of or within negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17145873 GOA
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17145873 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
27353365 GOA
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
18541373 GOA
involved in proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
18541373 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
24105792 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
14765125 GOA
acts upstream of or within regulation of MAPK cascade IDA
IDA: Inferred from direct assay
17145873 GOA
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17145873 GOA
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
18541373 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endoplasmic reticulum tubular network IDA
IDA: Inferred from direct assay
27353365 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
27353365 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF41 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 54)

USP8_interact

USP8_interact: USP8 interacting (137 - 315)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NRDP1

  • RING-type E3 ubiquitin transferase NRDP1

RNF41 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
RNF41 Q9H4P4 ARL6IP4 Homo sapiens Q66PJ3-3
Y2H Array
25416956
Intra
RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Array
25416956
Intra
RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Array
32296183
Intra
RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RNF41 Q9H4P4 HOMER2 Homo sapiens Q9NSB8
Y2H Array
25416956
Intra
RNF41 Q9H4P4 ASB6 Homo sapiens Q9NWX5
Validated Y2H
32296183
Intra
RNF41 Q9H4P4 ASB6 Homo sapiens Q9NWX5
Y2H Array
25416956
Intra
RNF41 Q9H4P4 TTC1 Homo sapiens Q99614
Validated Y2H
25416956
Intra
RNF41 Q9H4P4 TTC1 Homo sapiens Q99614
Y2H Array
25416956
Intra
RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Y2H Array
32296183
Intra
RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Anti Tag CoIP
26496610
Intra
RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra
RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Anti Tag CoIP
33961781
Intra
RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
RNF41 Q9H4P4 RFC4 Homo sapiens P35249
Y2H Array
25416956
Intra
RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Y2H Array
32296183
Intra
RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Validated Y2H
32296183
Intra
RNF41 Q9H4P4 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Y2H Array
25416956
Intra
RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Validated Y2H
25416956
Intra
RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Y2H Prey Pooling
32296183
Intra
RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Anti Tag CoIP
33961781
Intra
RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12092 RNF41 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus RNF41 MGD MGI:1914838
Canis familiaris RNF41 VGNC VGNC:45670
Bos taurus RNF41 VGNC VGNC:34067
Rattus norvegicus RNF41 RGD RGD:1309557
Others RNF41 NCBI