FDPS - farnesyl diphosphate synthase Gene

Also Known as FPS; FPPS; POROK9

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2224

About FDPS

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,308,866-155,320,665 (from NCBI)

This gene has 21 transcripts (splice variants), 229 orthologues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 72.6), duodenum (RPKM 62.1) and 25 other tissues.

Summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in Cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

FDPS Products (7)

mRNA Protein Name
NM_001135821.2 NP_001129293.1 farnesyl pyrophosphate synthase isoform a
NM_001135822.2 NP_001129294.1 farnesyl pyrophosphate synthase isoform b
NM_001242824.2 NP_001229753.1 farnesyl pyrophosphate synthase isoform b
NM_001242825.2 NP_001229754.1 farnesyl pyrophosphate synthase isoform c
NM_001378424.1 NP_001365353.1 farnesyl pyrophosphate synthase isoform b
NM_001378425.1 NP_001365354.1 farnesyl pyrophosphate synthase isoform b
NM_002004.4 NP_001995.1 farnesyl pyrophosphate synthase isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytosol IDA
IDA: Inferred from direct assay
17198737 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17198737 GOA
located in peroxisome IDA
IDA: Inferred from direct assay
17198737 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FDPS Protein Structure

polyprenyl_synt

polyprenyl_synt: Polyprenyl synthetase (111 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

farnesyl pyrophosphate synthase

  • (2E,6E)-farnesyl diphosphate synthase

FDPS Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
FDPS P14324 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
FDPS P14324 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
FDPS P14324 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
FDPS P14324 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FDPS Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75197 FDPS Protein, Human (His) P14324-2/NP_001129294.1 (M1-K353) ≥ 95%, as determined by Bis-Tris PAGE.

FDPS 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83072 FDPS Antibody (YA2817) WB, IHC-P Human, Hamster
HY-P83072A FDPS Antibody (YA2817)(PBS only) WB, IHC-P Human, Hamster

関連疾患

Diseases Alias
Porokeratosis 9, Multiple Types

  • POROK9
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Punctate Porokeratosis

  • Porokeratosis, Punctate

  • Keratoderma, Palmoplantar, Punctate Type Ii
Osteonecrosis

  • Bone Necrosis

  • Avascular Necrosis Of Bone

  • Aseptic Necrosis

  • Necrosis Of Bone Nos

  • Aseptic Osteonecrosis

  • Aseptic Necrosis Of Bone, Site Unspecified

  • Aseptic Or Avascular Bone Necrosis

  • Aseptic Necrosis Of Bone

  • Necrotic Bone

  • Necrotizing Bone

  • Spontaneous Osteonecrosis

  • Osteoradionecrosis
Linear Porokeratosis

  • Congenital Facial Linear Porokeratosis

  • Porokeratosis, Linear
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency

  • Congenital Myasthenic Syndrome 2c

  • CMS2C

  • Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency

  • Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency
Mammary Paget'S Disease

  • Paget'S Disease

  • Mammary Paget Disease

  • Paget'S Disease Of The Breast

  • Paget Disease Of The Breast

  • Paget'S Disease Of The Nipple

  • Paget'S Disease, Mammary

  • Paget Cell Neoplasm

  • Paget Disease Of The Nipple

  • Pagets Disease Mammary

  • Osteitis Deformans
Ischemic Bone Disease
Bone Disease

  • Bone Diseases

  • Skeletal Disease

  • Skeletal Disorder

  • Disorder Of Skeletal System
Glucocorticoid-Induced Osteoporosis

  • Steroid-Induced Osteoporosis
Breast Adenocarcinoma

  • Mammary Adenocarcinoma

  • Adenocarcinoma Of Breast
Paget'S Disease Of Bone

  • Osteitis Deformans

  • Paget Disease Of Bone

  • Osseous Paget'S Disease

  • Paget Disease Of Bone, Familial

  • Bone Paget Disease

  • Familial Paget'S Disease Of Bone

  • Paget'S Bone Disease

  • Familial Paget Disease Of Bone

  • Paget Disease, Bone

  • Pdb

  • Pagets Bone Disease
Bone Resorption Disease

  • Bone Resorption
Bone Remodeling Disease
Trypanosomiasis
Brittle Bone Disorder

  • Osteogenesis Imperfecta

  • Brittle Bone Disease

  • Fragilitas Ossium

  • Osteopsathyrosis

  • Lobstein Disease

  • Oi

  • Vrolik Disease

  • Lobstein'S Disease

  • Lobstein'S Syndrome

  • Vrolik'S Disease

  • Porak And Durante Disease

  • Glass Bone Disease

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal

  • Osteogenesis Imperfecta, Recessive Perinatal Lethal

  • Brittle Bone Syndrome

  • Oi - [Osteogenesis Imperfecta]

  • Ossium Fragility

  • Osteitis Fragilitans

  • Bony Fragility

  • Blue Sclera With Fragility Of Bone And Deafness

  • White Blue Sclera - Fragility Of Bone - Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-106950A Fosfructose trisodium 98.0% Unkown
HY-148077 Phosphoglycolohydroxamic acid Inhibitor 98.0% Unkown
HY-E70075 α-Glycerophosphate Dehydrogenase-Triosephosphate / Unkown
HY-B0631S Alendronic acid-d6 99.78% Unkown
HY-RS04853 FDPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17189 Fdps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23640 Fdps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus FDPS RGD RGD:68953
Mus musculus FDPS MGD MGI:104888
Macaca mulatta FDPS VGNC VGNC:106366
Canis familiaris FDPS VGNC VGNC:40812
Others FDPS NCBI